Detailed information of TA system TA288715

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3381768..3383469
• Replicon: chromosome
• Accession: NZ_LR698987
• Organism: Leminorella richardii isolate MGYG-HGUT-02385

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: FX055_RS15390
• Protein ID: WP_111741510.1
• Coordinates: 3382537..3383469 (+)
• Length: 311 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: FX055_RS15385
• Protein ID: WP_172622636.1
• Coordinates: 3381768..3382550 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FX055_RS15360	3377092..3378123	+	1032	WP_170126559.1	DUF1176 domain-containing protein	-
FX055_RS15365	3378200..3379066	-	867	WP_111741507.1	LysR family transcriptional regulator	-
FX055_RS15370	3379344..3380231	+	888	WP_111741508.1	class A beta-lactamase	-
FX055_RS15380	3380743..3381210	-	468	WP_111741509.1	hypothetical protein	-
FX055_RS15385	3381768..3382550	+	783	WP_172622636.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
FX055_RS15390	3382537..3383469	+	933	WP_111741510.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FX055_RS15395	3384129..3385160	-	1032	WP_111741511.1	4-hydroxy-2-oxovalerate aldolase	-
FX055_RS15400	3385157..3386107	-	951	WP_111741512.1	acetaldehyde dehydrogenase (acetylating)	-
FX055_RS15405	3386104..3386901	-	798	WP_111741513.1	2-keto-4-pentenoate hydratase	-
FX055_RS15410	3386916..3387785	-	870	WP_111741514.1	alpha/beta fold hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 311 a.a.
• Molecular weight: 35069.49 Da
• Isoelectric Point: 7.7368

>T288715 WP_111741510.1 NZ_LR698987:3382537-3383469 [Leminorella richardii]
MDLRDSYARQVRLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTFADRDTDLAAINDALKRITASLNSK
PGITAIRQENKADEKRIIVNTTDAQIKIEVSPVWRGLLLPPTEMPVCEQVEMEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLKKPGLTREIFDGFLCYLAGHPRPIAELLTPNWDTARIATLYAQEFSGMTTQRETSLESLLSVTTLLPQA
LKSHLTDRDRQFLLSYKQNTPDWSLYRYPEIQHLPAIRWKLRNLAVLKEKNPAKNTAAVSKLEGVLEQYF

Nucleotide

• Length: 933 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29329.62 Da
• Isoelectric Point: 8.1223

>AT288715 WP_172622636.1 NZ_LR698987:3381768-3382550 [Leminorella richardii]
MPNYLNWLMQNTLPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGRDPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGRQQIWLALPAYVKLPGWFATFEQSATFVTLYTSGLTVDITLLTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVMLYLARRNEHPYFRYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp