288713

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1628137..1628783 Replicon chromosome
Accession NZ_LR698987
Organism Leminorella richardii isolate MGYG-HGUT-02385

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FX055_RS07515 Protein ID WP_111740118.1
Coordinates 1628137..1628412 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FX055_RS07520 Protein ID WP_111742031.1
Coordinates 1628415..1628783 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX055_RS07490 1623721..1625077 + 1357 Protein_1462 MFS transporter -
FX055_RS07495 1625080..1625876 + 797 Protein_1463 sugar phosphate isomerase/epimerase -
FX055_RS07500 1625906..1626763 + 858 WP_111740115.1 oxidoreductase -
FX055_RS07505 1626945..1627649 + 705 WP_111740116.1 transcriptional regulator NanR -
FX055_RS07510 1627661..1627975 + 315 WP_111740117.1 hypothetical protein -
FX055_RS07515 1628137..1628412 + 276 WP_111740118.1 type II toxin-antitoxin system HicA family toxin Toxin
FX055_RS07520 1628415..1628783 + 369 WP_111742031.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FX055_RS07525 1628882..1629931 - 1050 WP_111740119.1 DUF695 domain-containing protein -
FX055_RS07530 1630266..1630886 - 621 WP_111740120.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE -
FX055_RS07535 1630880..1631656 - 777 WP_111740121.1 imidazole glycerol phosphate synthase subunit HisF -
FX055_RS07540 1631638..1632375 - 738 WP_111740122.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
FX055_RS07545 1632382..1632969 - 588 WP_111740123.1 imidazole glycerol phosphate synthase subunit HisH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(63-115)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 9942.61 Da        Isoelectric Point: 10.1492

>T288713 WP_111740118.1 NZ_LR698987:1628137-1628412 [Leminorella richardii]
MQEKVLLLRKKQYSTLSQLFKIPALAGIKWKDIESLVIALGGEVQEGNGSRVKFFLAGSIAHFHRPHPSPDTDKGAVVSV
GDWLMSLGVTP

Download         Length: 276 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13736.62 Da        Isoelectric Point: 5.6859

>AT288713 WP_111742031.1 NZ_LR698987:1628415-1628783 [Leminorella richardii]
MKKQPDINTLNTMVVAGQPAIISFVPELGAFRGRFLGLSGYCDFVADSISALKHEGEISLREYLEDCKEHGIEPYARKEK
QRTFTLRYPESFGEQLEHAAAASEVSLNSFIVDVLKERLSRQ

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References