Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 562534..563170 Replicon chromosome
Accession NZ_LR698983
Organism Bacillus licheniformis isolate MGYG-HGUT-02357

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag FX000_RS02825 Protein ID WP_003179128.1
Coordinates 562820..563170 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag FX000_RS02820 Protein ID WP_006638778.1
Coordinates 562534..562815 (+) Length 94 a.a.

Genomic Context

FX000_RS02800FX000_RS02810FX000_RS02815FX000_RS02820FX000_RS02825FX000_RS02830FX000_RS02835FX000_RS02840FX000_RS02845FX000_RS02850FX000_RS02855FX000_RS02860FX000_RS02865FX000_RS02805
Location: 557649..559130 (1482 bp)
Type: Others
Protein ID: WP_009330132.1
Location: 560069..561028 (960 bp)
Type: Others
Protein ID: WP_152847888.1
Location: 561253..562422 (1170 bp)
Type: Others
Protein ID: WP_026080763.1
Location: 562534..562815 (282 bp)
Type: Antitoxin
Protein ID: WP_006638778.1
Location: 562820..563170 (351 bp)
Type: Toxin
Protein ID: WP_003179128.1
Location: 563288..564115 (828 bp)
Type: Others
Protein ID: WP_003179130.1
Location: 564119..564484 (366 bp)
Type: Others
Protein ID: WP_003179132.1
Location: 564487..564888 (402 bp)
Type: Others
Protein ID: WP_003179135.1
Location: 564899..565906 (1008 bp)
Type: Others
Protein ID: WP_003179137.1
Location: 565965..566291 (327 bp)
Type: Others
Protein ID: WP_003179140.1
Location: 566291..566776 (486 bp)
Type: Others
Protein ID: WP_003179142.1
Location: 566742..567533 (792 bp)
Type: Others
Protein ID: WP_003179144.1
Location: 567530..568129 (600 bp)
Type: Others
Protein ID: WP_003179145.1
Location: 559127..559726 (600 bp)
Type: Others
Protein ID: WP_003179118.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FX000_RS02800557649..559130+1482WP_009330132.1PH domain-containing protein-
FX000_RS02805559127..559726-600WP_003179118.1rhomboid family intramembrane serine protease-
FX000_RS02810560069..561028+960WP_152847888.1outer membrane lipoprotein carrier protein LolA-
FX000_RS02815561253..562422+1170WP_026080763.1alanine racemase-
FX000_RS02820562534..562815+282WP_006638778.1hypothetical proteinAntitoxin
FX000_RS02825562820..563170+351WP_003179128.1type II toxin-antitoxin system endoribonuclease NdoAToxin
FX000_RS02830563288..564115+828WP_003179130.1RsbT co-antagonist protein RsbRA-
FX000_RS02835564119..564484+366WP_003179132.1STAS domain-containing protein-
FX000_RS02840564487..564888+402WP_003179135.1anti-sigma regulatory factor-
FX000_RS02845564899..565906+1008WP_003179137.1PP2C family protein-serine/threonine phosphatase-
FX000_RS02850565965..566291+327WP_003179140.1anti-sigma factor antagonist-
FX000_RS02855566291..566776+486WP_003179142.1anti-sigma B factor RsbW-
FX000_RS02860566742..567533+792WP_003179144.1RNA polymerase sigma factor SigB-
FX000_RS02865567530..568129+600WP_003179145.1SpoIIE family protein phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T288703 WP_003179128.1 NZ_LR698983:562820-563170 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT288703 WP_006638778.1 NZ_LR698983:562534-562815 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6I7FHI4

Antitoxin

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Source
ID
Structure
AlphaFold DBM5PDU2

References