Detailed information of TA system TA288701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higB-toxA/Tad-PHA01976
• Location: 2211262..2211919
• Replicon: chromosome
• Accession: NZ_LR698982
• Organism: Gordonibacter urolithinfaciens isolate MGYG-HGUT-02352

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FX079_RS14385
• Protein ID: WP_157780568.1
• Coordinates: 2211262..2211627 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: FX079_RS09605
• Protein ID: WP_096227865.1
• Coordinates: 2211620..2211919 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FX079_RS09580	2206834..2207811	+	978	WP_096227861.1	phosphate ABC transporter permease PstA	-
FX079_RS09585	2207804..2208670	+	867	WP_096227862.1	phosphate ABC transporter ATP-binding protein	-
FX079_RS09590	2208790..2209479	+	690	WP_015539548.1	response regulator transcription factor	-
FX079_RS09595	2209532..2210950	+	1419	WP_096227863.1	two-component sensor histidine kinase	-
FX079_RS14385	2211262..2211627	+	366	WP_157780568.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FX079_RS09605	2211620..2211919	+	300	WP_096227865.1	helix-turn-helix transcriptional regulator	Antitoxin
FX079_RS09610	2212498..2213847	+	1350	WP_096228652.1	replication-associated recombination protein A	-
FX079_RS09615	2213957..2214646	+	690	Protein_1878	DUF948 domain-containing protein	-
FX079_RS09620	2214737..2216032	+	1296	WP_172623286.1	AI-2E family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14508.77 Da
• Isoelectric Point: 10.5359

>T288701 WP_157780568.1 NZ_LR698982:2211262-2211627 [Gordonibacter urolithinfaciens]
MYKVELYHDAKGRSELLDTLRKLEDKSSTDKEARTAYLSMLKAISELEGHGTRIGMPTVRHVRGEIWELRPKSQRVFFFF
WKDNTFVLLHSYIKKTQKTPRREIMKAERKKRDWIARHADE

Nucleotide

• Length: 366 bp

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11179.91 Da
• Isoelectric Point: 6.9835

>AT288701 WP_096227865.1 NZ_LR698982:2211620-2211919 [Gordonibacter urolithinfaciens]
MSKNEGCYTFQDYLKEAKLTPAEREEIRLDVELTGRLIEAREARGMTQRDLAEASGLKQPAIARIESHRSVPRVDTLLKL
LVPLGYTLKIVPLEGSDRL

Nucleotide

• Length: 300 bp