Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 284588..285201 Replicon chromosome
Accession NZ_LR698961
Organism Helicobacter cinaedi isolate MGYG-HGUT-01432

Toxin (Protein)


Gene name vapC Uniprot ID I7GSY6
Locus tag FXY34_RS01445 Protein ID WP_002957230.1
Coordinates 284588..284989 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID I7HE84
Locus tag FXY34_RS01450 Protein ID WP_002957229.1
Coordinates 284977..285201 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXY34_RS01420 281513..283204 - 1692 WP_002957237.1 DUF262 domain-containing HNH endonuclease family protein -
FXY34_RS01425 283398..283604 - 207 WP_002957235.1 hypothetical protein -
FXY34_RS01430 283520..283717 - 198 WP_002957234.1 hypothetical protein -
FXY34_RS01435 283752..283940 - 189 WP_014666336.1 hypothetical protein -
FXY34_RS01440 284015..284386 - 372 WP_002957232.1 hypothetical protein -
FXY34_RS01445 284588..284989 - 402 WP_002957230.1 type II toxin-antitoxin system VapC family toxin Toxin
FXY34_RS01450 284977..285201 - 225 WP_002957229.1 hypothetical protein Antitoxin
FXY34_RS01455 285337..286273 + 937 Protein_283 WYL domain-containing protein -
FXY34_RS01460 286416..287090 + 675 WP_002957227.1 hypothetical protein -
FXY34_RS01465 287139..288512 + 1374 WP_015453250.1 U32 family peptidase -
FXY34_RS01470 288516..289415 - 900 WP_002957225.1 ATP-binding cassette domain-containing protein -
FXY34_RS01475 289412..290089 - 678 WP_172618402.1 molybdate ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15266.77 Da        Isoelectric Point: 7.9901

>T288693 WP_002957230.1 NZ_LR698961:c284989-284588 [Helicobacter cinaedi]
MAKIMLDTNICIYIINNKPQYIKDRFLQYRIGDIAISSISVAELYFGVEKSQYKEANTNALNTFLTHLEVIDFAHKEALT
YAKIRADLEYKKSLIGAMDMLISAVALANDLTLITNNTKEFQRVKNLKIENWV

Download         Length: 402 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8508.80 Da        Isoelectric Point: 9.9129

>AT288693 WP_002957229.1 NZ_LR698961:c285201-284977 [Helicobacter cinaedi]
MKAKVFKSGNSLAIRLPKALNLTKDCEFNIKQINNNIVLTPANSNWDSLFSAIDSFKGEIKRDELILQDREWQK

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I7GSY6

Antitoxin

Source ID Structure
AlphaFold DB A0A809NJV2

References