Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1117331..1117955 Replicon chromosome
Accession NZ_LR698956
Organism Helicobacter pylori isolate MGYG-HGUT-01357

Toxin (Protein)


Gene name relE Uniprot ID E6S2G8
Locus tag FXY05_RS05540 Protein ID WP_000916177.1
Coordinates 1117331..1117597 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E6S2G9
Locus tag FXY05_RS05545 Protein ID WP_001133877.1
Coordinates 1117578..1117955 (-) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXY05_RS05520 1113984..1114751 - 768 WP_000242364.1 ABC transporter ATP-binding protein -
FXY05_RS05525 1114751..1115731 - 981 WP_000921438.1 iron ABC transporter permease -
FXY05_RS05530 1115724..1116572 - 849 WP_000504110.1 SDR family oxidoreductase -
FXY05_RS05535 1116712..1117236 + 525 WP_001135614.1 acyl-CoA thioesterase -
FXY05_RS05540 1117331..1117597 - 267 WP_000916177.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FXY05_RS05545 1117578..1117955 - 378 WP_001133877.1 hypothetical protein Antitoxin
FXY05_RS05550 1118547..1120781 - 2235 WP_000716215.1 Hop family adhesin BabA -
FXY05_RS05565 1121302..1121823 + 522 WP_000427273.1 hypothetical protein -
FXY05_RS05570 1121774..1122886 - 1113 WP_000115675.1 hydrogenase formation protein HypD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-88)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10331.19 Da        Isoelectric Point: 9.6561

>T288692 WP_000916177.1 NZ_LR698956:c1117597-1117331 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVRDDELILVR
LGSHSELF

Download         Length: 267 bp


Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14616.66 Da        Isoelectric Point: 9.6856

>AT288692 WP_001133877.1 NZ_LR698956:c1117955-1117578 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKKMQNDRVSFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDGKRGCCL
GHKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVKTQS

Download         Length: 378 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A402E178


Antitoxin

Source ID Structure
AlphaFold DB E6S2G9

References