Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 2226023..2226530 Replicon chromosome
Accession NZ_LR698955
Organism Fusobacterium nucleatum isolate MGYG-HGUT-01347

Toxin (Protein)


Gene name yoeB Uniprot ID C7XST6
Locus tag FXY54_RS10740 Protein ID WP_020789278.1
Coordinates 2226023..2226283 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID U7TRN8
Locus tag FXY54_RS10745 Protein ID WP_005892688.1
Coordinates 2226276..2226530 (-) Length 85 a.a.

Genomic Context

FXY54_RS10715FXY54_RS10720FXY54_RS10725FXY54_RS10730FXY54_RS10735FXY54_RS10740FXY54_RS10745FXY54_RS10750FXY54_RS10755FXY54_RS10760
Location: 2221588..2222865 (1278 bp)
Type: Others
Protein ID: WP_008800438.1
Location: 2222949..2223335 (387 bp)
Type: Others
Protein ID: WP_008796539.1
Location: 2223408..2224604 (1197 bp)
Type: Others
Protein ID: WP_008796538.1
Location: 2224683..2225333 (651 bp)
Type: Others
Protein ID: WP_008800437.1
Location: 2225524..2226006 (483 bp)
Type: Others
Protein ID: WP_008800436.1
Location: 2226023..2226283 (261 bp)
Type: Toxin
Protein ID: WP_020789278.1
Location: 2226276..2226530 (255 bp)
Type: Antitoxin
Protein ID: WP_005892688.1
Location: 2226658..2227866 (1209 bp)
Type: Others
Protein ID: WP_020789277.1
Location: 2228100..2229374 (1275 bp)
Type: Others
Protein ID: WP_008800433.1
Location: 2229522..2229884 (363 bp)
Type: Others
Protein ID: WP_008796531.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FXY54_RS107152221588..2222865-1278WP_008800438.1D-alanyl-D-alanine carboxypeptidase-
FXY54_RS107202222949..2223335-387WP_008796539.1Fe-S cluster assembly scaffold protein NifU-
FXY54_RS107252223408..2224604-1197WP_008796538.1cysteine desulfurase NifS-
FXY54_RS107302224683..2225333-651WP_008800437.1endonuclease III-
FXY54_RS107352225524..2226006-483WP_008800436.1GNAT family N-acetyltransferase-
FXY54_RS107402226023..2226283-261WP_020789278.1Txe/YoeB family addiction module toxinToxin
FXY54_RS107452226276..2226530-255WP_005892688.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
FXY54_RS107502226658..2227866-1209WP_020789277.1tyrosine--tRNA ligase-
FXY54_RS107552228100..2229374-1275WP_008800433.1branched-chain amino acid transport system II carrier protein-
FXY54_RS107602229522..2229884-363WP_008796531.1arsenate reductase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10275.79 Da        Isoelectric Point: 9.3654

>T288691 WP_020789278.1 NZ_LR698955:c2226283-2226023 [Fusobacterium nucleatum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGALNGIGKPEVLKNENAYSRRIDEKNRLVYRIVDGVIWIIAC
KGHYEE

Download         Length: 261 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9824.17 Da        Isoelectric Point: 4.4453

>AT288691 WP_005892688.1 NZ_LR698955:c2226530-2226276 [Fusobacterium nucleatum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1E9ETF6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A806UAF3

References