Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 219631..220145 Replicon chromosome
Accession NZ_LR698955
Organism Fusobacterium nucleatum isolate MGYG-HGUT-01347

Toxin (Protein)


Gene name relB Uniprot ID C7XRY4
Locus tag FXY54_RS01125 Protein ID WP_008800343.1
Coordinates 219888..220145 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C7XRY5
Locus tag FXY54_RS01120 Protein ID WP_008800344.1
Coordinates 219631..219888 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXY54_RS01100 214769..216862 + 2094 WP_008800348.1 outer membrane protein assembly factor -
FXY54_RS01105 216903..217376 + 474 WP_008800347.1 OmpH family outer membrane protein -
FXY54_RS01110 217399..218397 + 999 WP_008800346.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
FXY54_RS01115 218440..219510 + 1071 WP_008800345.1 glycerophosphodiester phosphodiesterase -
FXY54_RS01120 219631..219888 + 258 WP_008800344.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FXY54_RS01125 219888..220145 + 258 WP_008800343.1 Txe/YoeB family addiction module toxin Toxin
FXY54_RS01130 220261..221337 + 1077 WP_008800342.1 DHH family phosphoesterase -
FXY54_RS01135 221569..222306 + 738 WP_008800341.1 tRNA pseudouridine(38-40) synthase TruA -
FXY54_RS01140 222448..223023 + 576 WP_008800340.1 aminoacyl-tRNA hydrolase -
FXY54_RS01145 223097..224404 + 1308 WP_008796317.1 electron transport complex subunit RsxC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10306.93 Da        Isoelectric Point: 9.6745

>T288690 WP_008800343.1 NZ_LR698955:219888-220145 [Fusobacterium nucleatum]
MLLTWTDFAWEQYEELQEKDKRLVKKINILIKDIKRNGNERIGKPEPLQHELSGYWSRRIDYKNRLVYKISDTQIIIVAC
ANHYK

Download         Length: 258 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10096.40 Da        Isoelectric Point: 4.7022

>AT288690 WP_008800344.1 NZ_LR698955:219631-219888 [Fusobacterium nucleatum]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LVEVD

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C7XRY4

Antitoxin

Source ID Structure
AlphaFold DB C7XRY5

References