Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 219631..220145 Replicon chromosome
Accession NZ_LR698955
Organism Fusobacterium nucleatum isolate MGYG-HGUT-01347

Toxin (Protein)


Gene name relB Uniprot ID C7XRY4
Locus tag FXY54_RS01125 Protein ID WP_008800343.1
Coordinates 219888..220145 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C7XRY5
Locus tag FXY54_RS01120 Protein ID WP_008800344.1
Coordinates 219631..219888 (+) Length 86 a.a.

Genomic Context

FXY54_RS01100FXY54_RS01105FXY54_RS01110FXY54_RS01115FXY54_RS01120FXY54_RS01125FXY54_RS01130FXY54_RS01135FXY54_RS01140FXY54_RS01145
Location: 214769..216862 (2094 bp)
Type: Others
Protein ID: WP_008800348.1
Location: 216903..217376 (474 bp)
Type: Others
Protein ID: WP_008800347.1
Location: 217399..218397 (999 bp)
Type: Others
Protein ID: WP_008800346.1
Location: 218440..219510 (1071 bp)
Type: Others
Protein ID: WP_008800345.1
Location: 219631..219888 (258 bp)
Type: Antitoxin
Protein ID: WP_008800344.1
Location: 219888..220145 (258 bp)
Type: Toxin
Protein ID: WP_008800343.1
Location: 220261..221337 (1077 bp)
Type: Others
Protein ID: WP_008800342.1
Location: 221569..222306 (738 bp)
Type: Others
Protein ID: WP_008800341.1
Location: 222448..223023 (576 bp)
Type: Others
Protein ID: WP_008800340.1
Location: 223097..224404 (1308 bp)
Type: Others
Protein ID: WP_008796317.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FXY54_RS01100214769..216862+2094WP_008800348.1outer membrane protein assembly factor-
FXY54_RS01105216903..217376+474WP_008800347.1OmpH family outer membrane protein-
FXY54_RS01110217399..218397+999WP_008800346.1UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase-
FXY54_RS01115218440..219510+1071WP_008800345.1glycerophosphodiester phosphodiesterase-
FXY54_RS01120219631..219888+258WP_008800344.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
FXY54_RS01125219888..220145+258WP_008800343.1Txe/YoeB family addiction module toxinToxin
FXY54_RS01130220261..221337+1077WP_008800342.1DHH family phosphoesterase-
FXY54_RS01135221569..222306+738WP_008800341.1tRNA pseudouridine(38-40) synthase TruA-
FXY54_RS01140222448..223023+576WP_008800340.1aminoacyl-tRNA hydrolase-
FXY54_RS01145223097..224404+1308WP_008796317.1electron transport complex subunit RsxC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10306.93 Da        Isoelectric Point: 9.6745

>T288690 WP_008800343.1 NZ_LR698955:219888-220145 [Fusobacterium nucleatum]
MLLTWTDFAWEQYEELQEKDKRLVKKINILIKDIKRNGNERIGKPEPLQHELSGYWSRRIDYKNRLVYKISDTQIIIVAC
ANHYK

Download         Length: 258 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10096.40 Da        Isoelectric Point: 4.7022

>AT288690 WP_008800344.1 NZ_LR698955:219631-219888 [Fusobacterium nucleatum]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LVEVD

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC7XRY4

Antitoxin

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Source
ID
Structure
AlphaFold DBC7XRY5

References