Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 1759537..1760173 Replicon chromosome
Accession NZ_LR698953
Organism Bifidobacterium longum isolate MGYG-HGUT-01292

Toxin (Protein)


Gene name mazF Uniprot ID W6EZW1
Locus tag FXZ20_RS08810 Protein ID WP_014484977.1
Coordinates 1759817..1760173 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID D6PAX1
Locus tag FXZ20_RS08805 Protein ID WP_012577921.1
Coordinates 1759537..1759830 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXZ20_RS08780 1754609..1755064 - 456 WP_012577916.1 Holliday junction resolvase RuvX -
FXZ20_RS08785 1755073..1757751 - 2679 WP_012577917.1 alanine--tRNA ligase -
FXZ20_RS13810 1757880..1758116 - 237 WP_012577918.1 hypothetical protein -
FXZ20_RS08795 1758116..1758514 - 399 WP_012577919.1 DUF948 domain-containing protein -
FXZ20_RS08800 1758597..1759280 - 684 WP_012577920.1 histidine phosphatase family protein -
FXZ20_RS08805 1759537..1759830 + 294 WP_012577921.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FXZ20_RS08810 1759817..1760173 + 357 WP_014484977.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FXZ20_RS08815 1760350..1760952 - 603 WP_012577923.1 transglutaminase family protein -
FXZ20_RS08820 1761057..1761413 - 357 WP_012577924.1 SdpI family protein -
FXZ20_RS08825 1761506..1761946 + 441 WP_012577925.1 cytidine deaminase -
FXZ20_RS08830 1762129..1762911 + 783 WP_012577926.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
FXZ20_RS08835 1763090..1763716 - 627 WP_007052130.1 30S ribosomal protein S4 -
FXZ20_RS08840 1763915..1764907 - 993 WP_012577927.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-53)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13302.25 Da        Isoelectric Point: 8.9603

>T288687 WP_014484977.1 NZ_LR698953:1759817-1760173 [Bifidobacterium longum]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA

Download         Length: 357 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10866.31 Da        Isoelectric Point: 4.2896

>AT288687 WP_012577921.1 NZ_LR698953:1759537-1759830 [Bifidobacterium longum]
MAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTPQ
IRDGAVILPEGWDDDED

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7D489

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2VTZ6

References