Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1104064..1104917 Replicon chromosome
Accession NZ_LR698953
Organism Bifidobacterium longum isolate MGYG-HGUT-01292

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FXZ20_RS05035 Protein ID WP_014484735.1
Coordinates 1104426..1104917 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7GQF3
Locus tag FXZ20_RS05030 Protein ID WP_012577299.1
Coordinates 1104064..1104426 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXZ20_RS05025 1101219..1103918 + 2700 WP_012577298.1 aconitate hydratase AcnA -
FXZ20_RS05030 1104064..1104426 + 363 WP_012577299.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FXZ20_RS05035 1104426..1104917 + 492 WP_014484735.1 PIN domain-containing protein Toxin
FXZ20_RS05040 1104977..1107082 - 2106 WP_012577301.1 DUF262 domain-containing protein -
FXZ20_RS05045 1107171..1107812 - 642 WP_013140893.1 GNAT family N-acetyltransferase -
FXZ20_RS05050 1107853..1107993 - 141 Protein_943 DNA-binding response regulator -
FXZ20_RS05055 1107947..1108165 + 219 WP_014484736.1 hypothetical protein -
FXZ20_RS05060 1108162..1109064 + 903 WP_014484737.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18398.02 Da        Isoelectric Point: 4.5590

>T288684 WP_014484735.1 NZ_LR698953:1104426-1104917 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLLSSAIRREFKPNESEVENFTRNF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14034.08 Da        Isoelectric Point: 5.0733

>AT288684 WP_012577299.1 NZ_LR698953:1104064-1104426 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGTGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B7GQF3

References