Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 15155..15720 Replicon chromosome
Accession NZ_LR698953
Organism Bifidobacterium longum isolate MGYG-HGUT-01292

Toxin (Protein)


Gene name relE Uniprot ID B7GSH0
Locus tag FXZ20_RS00065 Protein ID WP_012576472.1
Coordinates 15155..15445 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7GSH1
Locus tag FXZ20_RS00070 Protein ID WP_012576473.1
Coordinates 15442..15720 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXZ20_RS00040 10364..10930 + 567 WP_012576468.1 DUF3566 domain-containing protein -
FXZ20_RS00050 11576..12997 + 1422 WP_012576469.1 ATP-binding protein -
FXZ20_RS00055 13058..13282 - 225 WP_012576470.1 hypothetical protein -
FXZ20_RS00060 13433..14779 - 1347 WP_012576471.1 NADP-specific glutamate dehydrogenase -
FXZ20_RS00065 15155..15445 - 291 WP_012576472.1 type II toxin-antitoxin system YafQ family toxin Toxin
FXZ20_RS00070 15442..15720 - 279 WP_012576473.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FXZ20_RS00075 16143..16547 + 405 WP_126386265.1 hypothetical protein -
FXZ20_RS00080 16552..16947 - 396 WP_014484455.1 transposase -
FXZ20_RS00085 17287..17931 + 645 WP_012576475.1 hypothetical protein -
FXZ20_RS00090 18353..18544 - 192 WP_126386268.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10835.59 Da        Isoelectric Point: 10.3137

>T288683 WP_012576472.1 NZ_LR698953:c15445-15155 [Bifidobacterium longum]
MSGIRYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECYITPDLLLVYLIEKDVL
VLTLTRTGTHSGLFGK

Download         Length: 291 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10202.63 Da        Isoelectric Point: 6.3216

>AT288683 WP_012576473.1 NZ_LR698953:c15720-15442 [Bifidobacterium longum]
MSGTTTTVNVRMNAELKKQAEELFGELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B7GSH0

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8MHE5

References