288664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 383800..384730 Replicon chromosome
Accession NZ_LR698844
Organism Enterococcus faecalis isolate MGYG-HGUT-01694

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag FXY61_RS01920 Protein ID WP_002389521.1
Coordinates 383800..384456 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag FXY61_RS01925 Protein ID WP_000301765.1
Coordinates 384458..384730 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXY61_RS01895 378890..379120 - 231 WP_002355366.1 helix-turn-helix domain-containing protein -
FXY61_RS01905 379976..380221 - 246 WP_002358448.1 helix-turn-helix domain-containing protein -
FXY61_RS01910 380215..380616 - 402 WP_002364925.1 sigma-70 family RNA polymerase sigma factor -
FXY61_RS01920 383800..384456 - 657 WP_002389521.1 zeta toxin family protein Toxin
FXY61_RS01925 384458..384730 - 273 WP_000301765.1 antitoxin Antitoxin
FXY61_RS01930 384747..384956 - 210 WP_002389526.1 peptide-binding protein -
FXY61_RS01935 385026..385922 - 897 WP_096001398.1 ParA family protein -
FXY61_RS01940 385997..386119 - 123 Protein_358 topoisomerase -
FXY61_RS01945 386311..387594 - 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
FXY61_RS01950 387611..388537 - 927 WP_002389507.1 hypothetical protein -
FXY61_RS01955 388714..389442 + 729 WP_002389508.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ClpL EF0485 / bsh 379266..479894 100628


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 24481.80 Da        Isoelectric Point: 6.1232

>T288664 WP_002389521.1 NZ_LR698844:c384456-383800 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDKGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLLSDIRLYNREGVKLYSSLETG

Download         Length: 657 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10689.19 Da        Isoelectric Point: 6.4676

>AT288664 WP_000301765.1 NZ_LR698844:c384730-384458 [Enterococcus faecalis]
VAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References