Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1838979..1840487 Replicon chromosome
Accession NZ_LR657304
Organism Pseudomonas aeruginosa PAK

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PAKAF_RS08575 Protein ID WP_003119682.1
Coordinates 1838979..1839566 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag PAKAF_RS08580 Protein ID WP_003091607.1
Coordinates 1839633..1840487 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAKAF_RS08570 1835234..1838713 - 3480 WP_016253144.1 hybrid sensor histidine kinase/response regulator -
PAKAF_RS08575 1838979..1839566 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
PAKAF_RS08580 1839633..1840487 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
PAKAF_RS08585 1840584..1842749 + 2166 WP_016253145.1 TonB-dependent receptor family protein -
PAKAF_RS08590 1842924..1844798 + 1875 WP_003117607.1 MFS transporter -
PAKAF_RS08595 1844859..1845068 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T288659 WP_003119682.1 NZ_LR657304:1838979-1839566 [Pseudomonas aeruginosa PAK]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT288659 WP_003091607.1 NZ_LR657304:1839633-1840487 [Pseudomonas aeruginosa PAK]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References