288657

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141753..142258 Replicon chromosome
Accession NZ_LR657304
Organism Pseudomonas aeruginosa PAK

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PAKAF_RS00645 Protein ID WP_003083773.1
Coordinates 141753..142034 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag PAKAF_RS00650 Protein ID WP_003112628.1
Coordinates 142031..142258 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAKAF_RS00620 137004..138353 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
PAKAF_RS00625 138402..139088 + 687 WP_004351997.1 FadR family transcriptional regulator -
PAKAF_RS00630 139189..139923 + 735 WP_003117208.1 GntR family transcriptional regulator -
PAKAF_RS00635 140127..140513 + 387 WP_014602345.1 aegerolysin family protein -
PAKAF_RS00640 140545..141453 - 909 WP_003083769.1 LysR family transcriptional regulator -
PAKAF_RS00645 141753..142034 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PAKAF_RS00650 142031..142258 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
PAKAF_RS00655 142434..143054 - 621 WP_016252837.1 hypothetical protein -
PAKAF_RS00660 143155..143655 + 501 WP_003101228.1 LEA type 2 family protein -
PAKAF_RS00665 143728..144069 + 342 WP_003101229.1 alkylphosphonate utilization protein -
PAKAF_RS00670 144151..145578 - 1428 WP_016252838.1 GABA permease -
PAKAF_RS00675 145747..147240 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T288657 WP_003083773.1 NZ_LR657304:c142034-141753 [Pseudomonas aeruginosa PAK]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT288657 WP_003112628.1 NZ_LR657304:c142258-142031 [Pseudomonas aeruginosa PAK]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References