Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 1329287..1329923 Replicon chromosome
Accession NZ_LR655210
Organism Bifidobacterium longum subsp. infantis isolate B.longum_ssp_infantis_6

Toxin (Protein)


Gene name mazF Uniprot ID W6EZW1
Locus tag BILO16373828_RS06000 Protein ID WP_014484977.1
Coordinates 1329287..1329643 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID D6PAX1
Locus tag BILO16373828_RS06005 Protein ID WP_012577921.1
Coordinates 1329630..1329923 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BILO16373828_RS05970 1324553..1325545 + 993 WP_012577927.1 ABC transporter ATP-binding protein -
BILO16373828_RS05975 1325744..1326370 + 627 WP_007052130.1 30S ribosomal protein S4 -
BILO16373828_RS05980 1326549..1327331 - 783 WP_012577926.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
BILO16373828_RS05985 1327514..1327954 - 441 WP_012577925.1 cytidine deaminase -
BILO16373828_RS05990 1328047..1328403 + 357 WP_012577924.1 SdpI family protein -
BILO16373828_RS05995 1328508..1329110 + 603 WP_012577923.1 transglutaminase family protein -
BILO16373828_RS06000 1329287..1329643 - 357 WP_014484977.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BILO16373828_RS06005 1329630..1329923 - 294 WP_012577921.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BILO16373828_RS06010 1330180..1330863 + 684 WP_012577920.1 histidine phosphatase family protein -
BILO16373828_RS06015 1330946..1331344 + 399 WP_012577919.1 DUF948 domain-containing protein -
BILO16373828_RS13725 1331344..1331580 + 237 WP_012577918.1 hypothetical protein -
BILO16373828_RS06025 1331709..1334387 + 2679 WP_012577917.1 alanine--tRNA ligase -
BILO16373828_RS06030 1334396..1334851 + 456 WP_012577916.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-53)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13302.25 Da        Isoelectric Point: 8.9603

>T288653 WP_014484977.1 NZ_LR655210:c1329643-1329287 [Bifidobacterium longum subsp. infantis]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA

Download         Length: 357 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10866.31 Da        Isoelectric Point: 4.2896

>AT288653 WP_012577921.1 NZ_LR655210:c1329923-1329630 [Bifidobacterium longum subsp. infantis]
MAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTPQ
IRDGAVILPEGWDDDED

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7D489

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2VTZ6

References