Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 1256912..1257467 Replicon chromosome
Accession NZ_LR655210
Organism Bifidobacterium longum subsp. infantis isolate B.longum_ssp_infantis_6

Toxin (Protein)


Gene name mazF Uniprot ID B7GSS5
Locus tag BILO16373828_RS05610 Protein ID WP_003833460.1
Coordinates 1256912..1257235 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S2ZDC4
Locus tag BILO16373828_RS05615 Protein ID WP_003829112.1
Coordinates 1257222..1257467 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BILO16373828_RS05575 1251952..1252250 - 299 Protein_1029 IS256 family transposase -
BILO16373828_RS05585 1252720..1253985 - 1266 WP_012577985.1 Fic family protein -
BILO16373828_RS05595 1254515..1254880 - 366 WP_012577984.1 YccF domain-containing protein -
BILO16373828_RS05600 1255118..1255987 + 870 WP_003829104.1 class I SAM-dependent methyltransferase -
BILO16373828_RS05605 1256081..1256695 + 615 WP_012577983.1 cupin domain-containing protein -
BILO16373828_RS05610 1256912..1257235 - 324 WP_003833460.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BILO16373828_RS05615 1257222..1257467 - 246 WP_003829112.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BILO16373828_RS05620 1257641..1258897 + 1257 WP_003829116.1 HipA domain-containing protein -
BILO16373828_RS05625 1259162..1259366 + 205 Protein_1037 XRE family transcriptional regulator -
BILO16373828_RS05630 1259550..1260821 - 1272 WP_012577981.1 MFS transporter -
BILO16373828_RS05635 1260978..1261640 - 663 WP_012577980.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-56)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11829.64 Da        Isoelectric Point: 6.2932

>T288652 WP_003833460.1 NZ_LR655210:c1257235-1256912 [Bifidobacterium longum subsp. infantis]
MKRGEIRTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVVDDAAMANIGRQLMRVLGLL

Download         Length: 324 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9339.43 Da        Isoelectric Point: 4.5881

>AT288652 WP_003829112.1 NZ_LR655210:c1257467-1257222 [Bifidobacterium longum subsp. infantis]
MSMQIATRVDDEQAALFKETTRQLGTTPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDET
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0SL31

Antitoxin

Source ID Structure
AlphaFold DB A0A087B6Q6

References