Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 240945..241510 Replicon chromosome
Accession NZ_LR655210
Organism Bifidobacterium longum subsp. infantis isolate B.longum_ssp_infantis_6

Toxin (Protein)


Gene name relE Uniprot ID B7GSH0
Locus tag BILO16373828_RS01105 Protein ID WP_012576472.1
Coordinates 241220..241510 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7GSH1
Locus tag BILO16373828_RS01100 Protein ID WP_012576473.1
Coordinates 240945..241223 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BILO16373828_RS01080 238121..238312 + 192 WP_126386268.1 hypothetical protein -
BILO16373828_RS01085 238734..239378 - 645 WP_012576475.1 hypothetical protein -
BILO16373828_RS01090 239718..240113 + 396 WP_014484455.1 transposase -
BILO16373828_RS01095 240118..240465 - 348 WP_162010634.1 hypothetical protein -
BILO16373828_RS01100 240945..241223 + 279 WP_012576473.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BILO16373828_RS01105 241220..241510 + 291 WP_012576472.1 type II toxin-antitoxin system YafQ family toxin Toxin
BILO16373828_RS01110 241886..243232 + 1347 WP_012576471.1 NADP-specific glutamate dehydrogenase -
BILO16373828_RS01115 243383..243607 + 225 WP_012576470.1 hypothetical protein -
BILO16373828_RS01120 243668..245089 - 1422 WP_012576469.1 ATP-binding protein -
BILO16373828_RS01130 245735..246301 - 567 WP_012576468.1 DUF3566 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 230300..245089 14789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10835.59 Da        Isoelectric Point: 10.3137

>T288651 WP_012576472.1 NZ_LR655210:241220-241510 [Bifidobacterium longum subsp. infantis]
MSGIRYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECYITPDLLLVYLIEKDVL
VLTLTRTGTHSGLFGK

Download         Length: 291 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10202.63 Da        Isoelectric Point: 6.3216

>AT288651 WP_012576473.1 NZ_LR655210:240945-241223 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFGELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B7GSH0

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8MHE5

References