Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 1072823..1073459 Replicon chromosome
Accession NZ_LR655209
Organism Bifidobacterium breve isolate B.breve_1_mod

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BWLFYP14_RS04775 Protein ID WP_144180608.1
Coordinates 1072823..1073179 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K9C8D0
Locus tag BWLFYP14_RS04780 Protein ID WP_025221547.1
Coordinates 1073166..1073459 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWLFYP14_RS04745 1068023..1068934 + 912 WP_144180601.1 ABC transporter ATP-binding protein -
BWLFYP14_RS04750 1069131..1069757 + 627 WP_003829226.1 30S ribosomal protein S4 -
BWLFYP14_RS04755 1070095..1070877 - 783 WP_115767668.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
BWLFYP14_RS04760 1071015..1071500 - 486 WP_014483808.1 cytidine deaminase -
BWLFYP14_RS04765 1071590..1071946 + 357 WP_144180603.1 SdpI family protein -
BWLFYP14_RS04770 1072051..1072653 + 603 WP_144180606.1 transglutaminase family protein -
BWLFYP14_RS04775 1072823..1073179 - 357 WP_144180608.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BWLFYP14_RS04780 1073166..1073459 - 294 WP_025221547.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BWLFYP14_RS04785 1073710..1074384 + 675 WP_065456637.1 histidine phosphatase family protein -
BWLFYP14_RS04790 1074467..1074850 + 384 WP_016463075.1 DUF948 domain-containing protein -
BWLFYP14_RS04795 1074850..1075086 + 237 WP_003829239.1 hypothetical protein -
BWLFYP14_RS04800 1075182..1077860 + 2679 WP_106621641.1 alanine--tRNA ligase -
BWLFYP14_RS04805 1077869..1078321 + 453 WP_003829241.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-53)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13345.28 Da        Isoelectric Point: 9.5964

>T288649 WP_144180608.1 NZ_LR655209:c1073179-1072823 [Bifidobacterium breve]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFRDDGPTGRLSAYDAGRVAWAINELYPGLLA

Download         Length: 357 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10836.28 Da        Isoelectric Point: 4.2896

>AT288649 WP_025221547.1 NZ_LR655209:c1073459-1073166 [Bifidobacterium breve]
MAIKEKATISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTPQ
IRDGAVILPEGWDDDED

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9C8D0

References