Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1183800..1185556 Replicon chromosome
Accession NZ_LR595899
Organism Burkholderia pseudomallei isolate UKMR15

Toxin (Protein)


Gene name doc Uniprot ID B1H5R2
Locus tag HU776_RS23210 Protein ID WP_004524002.1
Coordinates 1183800..1184705 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag HU776_RS23215 Protein ID WP_004195450.1
Coordinates 1184702..1185556 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU776_RS23180 1179197..1180285 - 1089 WP_004184835.1 porin -
HU776_RS23185 1180718..1181035 + 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
HU776_RS23190 1181037..1181348 + 312 WP_004184841.1 hypothetical protein -
HU776_RS23195 1181383..1182450 + 1068 WP_004195457.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
HU776_RS23200 1182447..1183217 + 771 WP_004184755.1 SDR family oxidoreductase -
HU776_RS23205 1183256..1183783 + 528 WP_004524001.1 cupin domain-containing protein -
HU776_RS23210 1183800..1184705 + 906 WP_004524002.1 alpha/beta fold hydrolase Toxin
HU776_RS23215 1184702..1185556 + 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
HU776_RS23220 1185553..1186350 + 798 WP_004528161.1 SDR family oxidoreductase -
HU776_RS23225 1186343..1188016 + 1674 WP_004524004.1 thiamine pyrophosphate-binding protein -
HU776_RS23230 1188009..1188824 + 816 WP_004195445.1 aspartate dehydrogenase -
HU776_RS23235 1188850..1190340 + 1491 WP_004524006.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30556.69 Da        Isoelectric Point: 8.4944

>T288648 WP_004524002.1 NZ_LR595899:1183800-1184705 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT288648 WP_004195450.1 NZ_LR595899:1184702-1185556 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A095K1W1

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References