Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2121335..2123094 Replicon chromosome
Accession NZ_LR595897
Organism Burkholderia pseudomallei isolate UKMD286

Toxin (Protein)


Gene name hipA Uniprot ID B1H781
Locus tag UKMR15_RS26130 Protein ID WP_004525276.1
Coordinates 2121742..2123094 (+) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID C4I768
Locus tag UKMR15_RS26125 Protein ID WP_004536731.1
Coordinates 2121335..2121745 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UKMR15_RS26115 2117872..2120268 - 2397 WP_011205645.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -
UKMR15_RS26120 2120734..2120997 + 264 WP_004199789.1 hypothetical protein -
UKMR15_RS26125 2121335..2121745 + 411 WP_004536731.1 helix-turn-helix domain-containing protein Antitoxin
UKMR15_RS26130 2121742..2123094 + 1353 WP_004525276.1 type II toxin-antitoxin system HipA family toxin Toxin
UKMR15_RS26135 2123251..2123703 - 453 WP_004198842.1 hypothetical protein -
UKMR15_RS26140 2124127..2125041 - 915 WP_004198844.1 LysR family transcriptional regulator -
UKMR15_RS26145 2125208..2126161 + 954 WP_004187785.1 agmatinase -
UKMR15_RS26150 2126432..2126770 + 339 WP_004188037.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49790.80 Da        Isoelectric Point: 9.8300

>T288646 WP_004525276.1 NZ_LR595897:2121742-2123094 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTAGVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Download         Length: 1353 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14508.87 Da        Isoelectric Point: 11.8540

>AT288646 WP_004536731.1 NZ_LR595897:2121335-2121745 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTAAGARARAGARRAVPPASAPAPSAAGRAPRPARKRAAPKKREDW

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K3EM91

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8KZI9

References