Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
Location | 1183245..1185001 | Replicon | chromosome |
Accession | NZ_LR595897 | ||
Organism | Burkholderia pseudomallei isolate UKMD286 |
Toxin (Protein)
Gene name | doc | Uniprot ID | B1H5R2 |
Locus tag | UKMR15_RS22600 | Protein ID | WP_004524002.1 |
Coordinates | 1183245..1184150 (+) | Length | 302 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | Q63LW2 |
Locus tag | UKMR15_RS22605 | Protein ID | WP_004195450.1 |
Coordinates | 1184147..1185001 (+) | Length | 285 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
UKMR15_RS22570 | 1178642..1179730 | - | 1089 | WP_004184835.1 | porin | - |
UKMR15_RS22575 | 1180163..1180480 | + | 318 | WP_004184916.1 | non-heme iron oxygenase ferredoxin subunit | - |
UKMR15_RS22580 | 1180482..1180793 | + | 312 | WP_004184841.1 | hypothetical protein | - |
UKMR15_RS22585 | 1180828..1181895 | + | 1068 | WP_004195457.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
UKMR15_RS22590 | 1181892..1182662 | + | 771 | WP_004184755.1 | SDR family oxidoreductase | - |
UKMR15_RS22595 | 1182701..1183228 | + | 528 | WP_004524001.1 | cupin domain-containing protein | - |
UKMR15_RS22600 | 1183245..1184150 | + | 906 | WP_004524002.1 | alpha/beta fold hydrolase | Toxin |
UKMR15_RS22605 | 1184147..1185001 | + | 855 | WP_004195450.1 | IclR family transcriptional regulator | Antitoxin |
UKMR15_RS22610 | 1184998..1185795 | + | 798 | WP_004528161.1 | SDR family oxidoreductase | - |
UKMR15_RS22615 | 1185788..1187461 | + | 1674 | WP_004524004.1 | thiamine pyrophosphate-binding protein | - |
UKMR15_RS22620 | 1187454..1188269 | + | 816 | WP_004195445.1 | aspartate dehydrogenase | - |
UKMR15_RS22625 | 1188295..1189785 | + | 1491 | WP_119023960.1 | aldehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 302 a.a. Molecular weight: 30556.69 Da Isoelectric Point: 8.4944
>T288645 WP_004524002.1 NZ_LR595897:1183245-1184150 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
Download Length: 906 bp
Antitoxin
Download Length: 285 a.a. Molecular weight: 31152.56 Da Isoelectric Point: 6.8932
>AT288645 WP_004195450.1 NZ_LR595897:1184147-1185001 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
Download Length: 855 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A095K1W1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3N4FRW8 |