288644

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 534807..535344 Replicon chromosome
Accession NZ_LR595897
Organism Burkholderia pseudomallei isolate UKMD286

Toxin (Protein)


Gene name brnT Uniprot ID Q2T6G2
Locus tag UKMR15_RS19920 Protein ID WP_004549731.1
Coordinates 534807..535076 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag UKMR15_RS19925 Protein ID WP_004525420.1
Coordinates 535060..535344 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UKMR15_RS19885 530551..531591 - 1041 WP_197970191.1 ImmA/IrrE family metallo-endopeptidase -
UKMR15_RS19890 531807..532091 - 285 WP_009961460.1 type II toxin-antitoxin system HigB family toxin -
UKMR15_RS19895 532995..533237 - 243 WP_009961458.1 hypothetical protein -
UKMR15_RS19900 533285..533443 - 159 WP_004549802.1 hypothetical protein -
UKMR15_RS19905 533440..533682 - 243 WP_004545584.1 hypothetical protein -
UKMR15_RS19910 533820..533951 - 132 WP_009923452.1 bacteriophage protein Gp48 -
UKMR15_RS19915 533961..534236 - 276 WP_025988352.1 hypothetical protein -
UKMR15_RS19920 534807..535076 + 270 WP_004549731.1 BrnT family toxin Toxin
UKMR15_RS19925 535060..535344 + 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
UKMR15_RS19930 535991..536374 + 384 Protein_441 DDE-type integrase/transposase/recombinase -
UKMR15_RS19935 536337..536765 + 429 Protein_442 IS110 family transposase -
UKMR15_RS19940 536992..537108 - 117 Protein_443 IS3 family transposase -
UKMR15_RS19945 537355..538815 + 1461 WP_011326543.1 metallophosphoesterase -
UKMR15_RS19950 538974..540236 + 1263 WP_004537187.1 c-type cytochrome -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 516832..536374 19542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10157.46 Da        Isoelectric Point: 5.6831

>T288644 WP_004549731.1 NZ_LR595897:534807-535076 [Burkholderia pseudomallei]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT288644 WP_004525420.1 NZ_LR595897:535060-535344 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2T6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References