288643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2121823..2123582 Replicon chromosome
Accession NZ_LR595895
Organism Burkholderia pseudomallei isolate UKMPMC2000

Toxin (Protein)


Gene name hipA Uniprot ID B1H781
Locus tag HU777_RS26305 Protein ID WP_004525276.1
Coordinates 2122230..2123582 (+) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID C4I768
Locus tag HU777_RS26300 Protein ID WP_004536731.1
Coordinates 2121823..2122233 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU777_RS26290 2118360..2120756 - 2397 WP_011205645.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -
HU777_RS26295 2121222..2121485 + 264 WP_004199789.1 hypothetical protein -
HU777_RS26300 2121823..2122233 + 411 WP_004536731.1 helix-turn-helix domain-containing protein Antitoxin
HU777_RS26305 2122230..2123582 + 1353 WP_004525276.1 type II toxin-antitoxin system HipA family toxin Toxin
HU777_RS26310 2123739..2124191 - 453 WP_004198842.1 hypothetical protein -
HU777_RS26315 2124629..2125543 - 915 WP_004198844.1 LysR family transcriptional regulator -
HU777_RS26320 2125710..2126663 + 954 WP_004187785.1 agmatinase -
HU777_RS26325 2126934..2127272 + 339 WP_004188037.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49790.80 Da        Isoelectric Point: 9.8300

>T288643 WP_004525276.1 NZ_LR595895:2122230-2123582 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTAGVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Download         Length: 1353 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14508.87 Da        Isoelectric Point: 11.8540

>AT288643 WP_004536731.1 NZ_LR595895:2121823-2122233 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTAAGARARAGARRAVPPASAPAPSAAGRAPRPARKRAAPKKREDW

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K3EM91

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8KZI9

References