288642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1184472..1186228 Replicon chromosome
Accession NZ_LR595895
Organism Burkholderia pseudomallei isolate UKMPMC2000

Toxin (Protein)


Gene name doc Uniprot ID B1H5R2
Locus tag HU777_RS22790 Protein ID WP_004524002.1
Coordinates 1184472..1185377 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag HU777_RS22795 Protein ID WP_004195450.1
Coordinates 1185374..1186228 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU777_RS22760 1179869..1180957 - 1089 WP_004184835.1 porin -
HU777_RS22765 1181390..1181707 + 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
HU777_RS22770 1181709..1182020 + 312 WP_004184841.1 hypothetical protein -
HU777_RS22775 1182055..1183122 + 1068 WP_004195457.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
HU777_RS22780 1183119..1183889 + 771 WP_004184755.1 SDR family oxidoreductase -
HU777_RS22785 1183928..1184455 + 528 WP_004524001.1 cupin domain-containing protein -
HU777_RS22790 1184472..1185377 + 906 WP_004524002.1 alpha/beta fold hydrolase Toxin
HU777_RS22795 1185374..1186228 + 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
HU777_RS22800 1186225..1187022 + 798 WP_004528161.1 SDR family oxidoreductase -
HU777_RS22805 1187015..1188688 + 1674 WP_004524004.1 thiamine pyrophosphate-binding protein -
HU777_RS22810 1188681..1189496 + 816 WP_004195445.1 aspartate dehydrogenase -
HU777_RS22815 1189522..1191012 + 1491 WP_004524006.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30556.69 Da        Isoelectric Point: 8.4944

>T288642 WP_004524002.1 NZ_LR595895:1184472-1185377 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT288642 WP_004195450.1 NZ_LR595895:1185374-1186228 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A095K1W1

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References