Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 331072..331781 Replicon chromosome
Accession NC_020245
Organism Mycobacterium bovis BCG str. Korea 1168P

Toxin (Protein)


Gene name vapC Uniprot ID P9WF84
Locus tag K60_RS01460 Protein ID WP_003401406.1
Coordinates 331072..331500 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U4BRN8
Locus tag K60_RS01465 Protein ID WP_011799093.1
Coordinates 331524..331781 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K60_RS01435 326939..328072 - 1134 WP_003401394.1 hypothetical protein -
K60_RS01440 328069..328689 - 621 WP_003401397.1 TetR/AcrR family transcriptional regulator -
K60_RS01445 328786..329367 + 582 WP_003401399.1 VOC family protein -
K60_RS01450 329297..330022 - 726 WP_003902925.1 TetR/AcrR family transcriptional regulator -
K60_RS01455 330112..331032 + 921 WP_003401404.1 DUF2236 domain-containing protein -
K60_RS01460 331072..331500 - 429 WP_003401406.1 type II toxin-antitoxin system VapC family toxin Toxin
K60_RS01465 331524..331781 - 258 WP_011799093.1 ribbon-helix-helix domain-containing protein Antitoxin
K60_RS01470 331866..334616 - 2751 WP_011799094.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15887.27 Da        Isoelectric Point: 7.2214

>T28864 WP_003401406.1 NC_020245:c331500-331072 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHL
PTSPGPRHLVLLRKLCDEADASGDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI

Download         Length: 429 bp

>T28864 NC_020245:c331500-331072 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGTTCCTCATCGACGTCAACGTGCTGCTGGCTGCACACCGCGGTGACCATCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTTGCGGCCGACGACCCCTTCACAGTGCCGAACCTAGTGTGGGCGTCGTTCCTCCGGCTAACAACGAATC
GACGCATCTTCGAGATTCCGTCACCACGAGCGGATGCATTCGCATTCGTCGAAGCCGTCAACGCCCAGCCCCATCACCTT
CCGACAAGCCCCGGCCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGGGGCCATCGCCGTGGAGCATCACTGCGCCGTGGTGAGCCTGGATAGGGATTTCGCCCGGTTTGCCT
CTGTGCGCCATATTCGCCCGCCAATCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.32 Da        Isoelectric Point: 10.6530

>AT28864 WP_011799093.1 NC_020245:c331781-331524 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MRTTVSISDELLATAKRRARERGQSLGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNRVLSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT28864 NC_020245:c331781-331524 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGCGCACCACCGTGTCAATCTCCGATGAACTACTGGCTACCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAAGACGCCCTTCGGCGGGAGCTCGCCGCCGCCCGCACCGGCGGCGCCCGGCCAACCGTCCCCGTTTTTG
ACGCCGGCACCGGTCCGCGGCCAGGTATCGACCTAACCTCGAATAGGGTGTTGTCCGAAGTGCTCGACGAGGGTCTGGAA
CTGAACTCGCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRN8

References