Detailed information of TA system TA288639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelB(antitoxin)
• Location: 570646..571264
• Replicon: chromosome
• Accession: NZ_LR595857
• Organism: Streptococcus sp. NCTC 11567 strain NCTC11567

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FQT67_RS03055
• Protein ID: WP_003058081.1
• Coordinates: 570646..570987 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FQT67_RS03060
• Protein ID: WP_003058067.1
• Coordinates: 570977..571264 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQT67_RS03035	566109..567353	-	1245	WP_014612120.1	site-specific integrase	-
FQT67_RS03040	567364..567561	-	198	WP_003058094.1	transposase	-
FQT67_RS03045	567581..568684	-	1104	WP_046177356.1	CHAP domain-containing protein	-
FQT67_RS03050	568687..570588	-	1902	WP_003058051.1	hypothetical protein	-
FQT67_RS03055	570646..570987	-	342	WP_003058081.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FQT67_RS03060	570977..571264	-	288	WP_003058067.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FQT67_RS03065	571335..573833	-	2499	WP_003058044.1	ATP-binding protein	-
FQT67_RS03070	573817..574233	-	417	WP_003058056.1	conjugal transfer protein	-
FQT67_RS03075	574242..574460	-	219	WP_003058071.1	hypothetical protein	-
FQT67_RS03080	574457..575398	-	942	WP_003058075.1	conjugal transfer protein	-
FQT67_RS03085	575411..575674	-	264	WP_003058063.1	hypothetical protein	-
FQT67_RS03090	575684..575956	-	273	WP_046177355.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	566109..593452	27343

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-100)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (11-90)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13438.41 Da
• Isoelectric Point: 7.0067

>T288639 WP_003058081.1 NZ_LR595857:c570987-570646 [Streptococcus sp. NCTC 11567]
MAYNVQITKSAERDLDSIYQFYLDEFSEQSALKVIKSLQDAISFLYVSPLGYTDFDSKINRKIYPQGNLRMIPSKQYLIF
YLIREERVDVLRIIHSRTDYLNNLENLFKNLNL

Nucleotide

• Length: 342 bp

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10869.33 Da
• Isoelectric Point: 4.3885

>AT288639 WP_003058067.1 NZ_LR595857:c571264-570977 [Streptococcus sp. NCTC 11567]
MNTLARDRQYNFRVNADMLNQAKEILEEKHMSLPDALNLFVEQVVVTKDLPIKTPEQVQAESFLNELISELDEGYQDVLK
GNTKPANEVFAKYGL

Nucleotide

• Length: 288 bp