Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 278255..278867 Replicon chromosome
Accession NZ_LR595857
Organism Streptococcus sp. NCTC 11567 strain NCTC11567

Toxin (Protein)


Gene name parE Uniprot ID Q8E7D3
Locus tag FQT67_RS01545 Protein ID WP_000384859.1
Coordinates 278255..278590 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E7D2
Locus tag FQT67_RS01550 Protein ID WP_000259017.1
Coordinates 278580..278867 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQT67_RS01515 273454..274083 + 630 WP_046177566.1 hypothetical protein -
FQT67_RS01525 274395..275270 + 876 WP_000421240.1 hypothetical protein -
FQT67_RS01530 275306..275740 + 435 WP_001220479.1 hypothetical protein -
FQT67_RS01535 276056..277312 + 1257 WP_143936361.1 plasmid recombination protein -
FQT67_RS01540 277480..277950 + 471 WP_000130119.1 hypothetical protein -
FQT67_RS01545 278255..278590 - 336 WP_000384859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FQT67_RS01550 278580..278867 - 288 WP_000259017.1 hypothetical protein Antitoxin
FQT67_RS01555 279269..279631 - 363 WP_080554381.1 tyrosine-type recombinase/integrase -
FQT67_RS01560 279742..281463 + 1722 WP_046177550.1 PTS sugar transporter subunit IIA -
FQT67_RS01565 281465..281923 + 459 Protein_255 PTS sugar transporter subunit IIA -
FQT67_RS01570 281933..283273 + 1341 WP_046177549.1 PTS galactitol transporter subunit IIC -
FQT67_RS01575 283270..283554 + 285 WP_012766555.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 265788..281923 16135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13296.98 Da        Isoelectric Point: 4.6565

>T288638 WP_000384859.1 NZ_LR595857:c278590-278255 [Streptococcus sp. NCTC 11567]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.7271

>AT288638 WP_000259017.1 NZ_LR595857:c278867-278580 [Streptococcus sp. NCTC 11567]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076Z4V6

References