Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 5010216..5010792 Replicon chromosome
Accession NZ_LR595855
Organism Raoultella terrigena strain NCTC9189

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag FQU09_RS24235 Protein ID WP_115193645.1
Coordinates 5010505..5010792 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag FQU09_RS24230 Protein ID WP_115193644.1
Coordinates 5010216..5010518 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU09_RS24205 5005302..5006366 - 1065 WP_115193639.1 DUF2955 domain-containing protein -
FQU09_RS24210 5006356..5007423 - 1068 WP_115193640.1 HlyD family secretion protein -
FQU09_RS24215 5007430..5007894 - 465 WP_115193641.1 MarR family transcriptional regulator -
FQU09_RS24220 5008347..5008511 - 165 WP_115193642.1 DUF1127 domain-containing protein -
FQU09_RS24225 5008689..5010101 + 1413 WP_115193643.1 PLP-dependent aminotransferase family protein -
FQU09_RS24230 5010216..5010518 - 303 WP_115193644.1 BrnA antitoxin family protein Antitoxin
FQU09_RS24235 5010505..5010792 - 288 WP_115193645.1 BrnT family toxin Toxin
FQU09_RS24240 5010910..5011329 - 420 WP_115193646.1 FosA family fosfomycin resistance glutathione transferase -
FQU09_RS24245 5011333..5012232 - 900 WP_143967758.1 LysR family transcriptional regulator -
FQU09_RS24250 5012320..5013102 + 783 WP_115193648.1 NAD(P)H-dependent oxidoreductase -
FQU09_RS24255 5013249..5013827 + 579 WP_041143880.1 TetR/AcrR family transcriptional regulator -
FQU09_RS24260 5013872..5014687 + 816 WP_143967759.1 helix-turn-helix domain-containing protein -
FQU09_RS24265 5014684..5015202 + 519 WP_041143878.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10979.33 Da        Isoelectric Point: 6.6066

>T288637 WP_115193645.1 NZ_LR595855:c5010792-5010505 [Raoultella terrigena]
MPMEFEWDANKAASNLSKHGIRFEEAVLVFDDPQHLSHQDRYENGEHRWQTIGLVHGIIVILVVHSVRFESGAEVIRIIS
ARKADGKERSRYEHS

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11368.83 Da        Isoelectric Point: 9.3974

>AT288637 WP_115193644.1 NZ_LR595855:c5010518-5010216 [Raoultella terrigena]
MSTVKYKRDNPAGLSAQREDELRALAKKADGEIDYSDIPASGDEQWPDAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMNRDLGEK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References