Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4422920..4423539 Replicon chromosome
Accession NZ_LR595855
Organism Raoultella terrigena strain NCTC9189

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4Z516
Locus tag FQU09_RS21390 Protein ID WP_041144355.1
Coordinates 4423321..4423539 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8B4Z4D4
Locus tag FQU09_RS21385 Protein ID WP_041144356.1
Coordinates 4422920..4423294 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU09_RS21375 4418082..4419263 + 1182 WP_143967626.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FQU09_RS21380 4419298..4422444 + 3147 WP_041144357.1 multidrug efflux RND transporter permease subunit -
FQU09_RS21385 4422920..4423294 + 375 WP_041144356.1 Hha toxicity modulator TomB Antitoxin
FQU09_RS21390 4423321..4423539 + 219 WP_041144355.1 hemolysin expression modulator Hha Toxin
FQU09_RS21395 4423689..4424255 + 567 WP_041144354.1 maltose O-acetyltransferase -
FQU09_RS21400 4424354..4424821 + 468 WP_041144353.1 YlaC family protein -
FQU09_RS21405 4424793..4426250 - 1458 WP_143967627.1 PLP-dependent aminotransferase family protein -
FQU09_RS21410 4426352..4427062 + 711 WP_143967628.1 GNAT family N-acetyltransferase -
FQU09_RS21415 4427059..4427199 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FQU09_RS21420 4427202..4427462 - 261 WP_041144350.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8580.94 Da        Isoelectric Point: 7.9907

>T288636 WP_041144355.1 NZ_LR595855:4423321-4423539 [Raoultella terrigena]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELPDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14397.16 Da        Isoelectric Point: 4.8886

>AT288636 WP_041144356.1 NZ_LR595855:4422920-4423294 [Raoultella terrigena]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIDHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINSVDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4Z516

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4Z4D4

References