Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2919053..2920641 Replicon chromosome
Accession NZ_LR595855
Organism Raoultella terrigena strain NCTC9189

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FQU09_RS14135 Protein ID WP_041145486.1
Coordinates 2919053..2920372 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FQU09_RS14140 Protein ID WP_115193957.1
Coordinates 2920372..2920641 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU09_RS14110 2914574..2915860 + 1287 WP_167692446.1 glycoside hydrolase family 10 protein -
FQU09_RS14115 2916051..2916623 + 573 WP_115192788.1 peroxiredoxin -
FQU09_RS14120 2916639..2917871 + 1233 WP_123552387.1 thioredoxin family protein -
FQU09_RS14125 2917886..2918440 + 555 WP_143967150.1 sigma-70 family RNA polymerase sigma factor -
FQU09_RS14130 2918427..2919056 + 630 WP_041145487.1 DUF1109 family protein -
FQU09_RS14135 2919053..2920372 - 1320 WP_041145486.1 type II toxin-antitoxin system HipA family toxin Toxin
FQU09_RS14140 2920372..2920641 - 270 WP_115193957.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
FQU09_RS14145 2920837..2921397 - 561 WP_143967946.1 RNA polymerase sigma factor -
FQU09_RS14150 2921403..2921828 - 426 WP_115192791.1 hypothetical protein -
FQU09_RS14155 2921968..2922924 - 957 WP_143967151.1 hypothetical protein -
FQU09_RS14160 2923035..2924273 - 1239 WP_115193958.1 sensor domain-containing diguanylate cyclase -
FQU09_RS14165 2924319..2924507 + 189 WP_143967152.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 48592.79 Da        Isoelectric Point: 6.8435

>T288635 WP_041145486.1 NZ_LR595855:c2920372-2919053 [Raoultella terrigena]
MATLVTWMNNERVGELVKLANGAHQFRYEPRWLQNPRARPLSLSLPLQFGNITSDAVFNYFDNLLPDSPLVRDRIVKRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPEGAAPATGALTWEALDDARLDALLTAYRADIPLGMINGQEEFRISVAGAQEKTAL
LKMDDRWCIPTATTPTTHIIKLPIGEIRQPDAVLDLSESVDNEYLCLALARALGFAVPDAEIITTRSIRALAVARFDRRW
AQENTRLLRLPQEDLCQAFGIPSSMKYESDGGPGIASIMAFLLGSSEALKDRADFMKFIVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGAGLHISDLKLSMSLKASKGRKTEIQTIYPRHFLATAKEVGFAQQQMLEILRYFADNLP
RAVETVSASLPEDFSPTVYQAIISHTLRNHARLQSGLAG

Download         Length: 1320 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10137.54 Da        Isoelectric Point: 8.0441

>AT288635 WP_115193957.1 NZ_LR595855:c2920641-2920372 [Raoultella terrigena]
ITPPTIYSPAQLANHIKLVRQKNQWTQSDLARRIGIKQATISNFENHPDKTTLTTLFKILQSLEMTMVVCEKGATSGPEQ
QDSQRDLEW

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References