Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2827695..2828434 Replicon chromosome
Accession NZ_LR595855
Organism Raoultella terrigena strain NCTC9189

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag FQU09_RS13735 Protein ID WP_076947544.1
Coordinates 2827949..2828434 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A085GLQ4
Locus tag FQU09_RS13730 Protein ID WP_032611697.1
Coordinates 2827695..2827961 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU09_RS13705 2822878..2823978 - 1101 WP_123552332.1 amino acid ABC transporter permease -
FQU09_RS13710 2823994..2825286 - 1293 WP_143967118.1 amino acid ABC transporter permease -
FQU09_RS13715 2825237..2826262 - 1026 WP_041145578.1 amino acid ABC transporter substrate-binding protein -
FQU09_RS13720 2826954..2827556 + 603 WP_143967119.1 DJ-1/PfpI family protein -
FQU09_RS13730 2827695..2827961 + 267 WP_032611697.1 DUF1778 domain-containing protein Antitoxin
FQU09_RS13735 2827949..2828434 + 486 WP_076947544.1 GNAT family N-acetyltransferase Toxin
FQU09_RS13740 2828539..2830071 + 1533 WP_004118819.1 IS3 family transposase -
FQU09_RS13745 2830256..2830567 - 312 Protein_2665 DUF2255 family protein -
FQU09_RS13750 2830810..2831907 - 1098 WP_115192744.1 alpha/beta hydrolase -
FQU09_RS13755 2831888..2832784 + 897 WP_143967120.1 AraC family transcriptional regulator -
FQU09_RS13760 2832802..2833050 - 249 Protein_2668 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2827695..2847476 19781
- flank IS/Tn - - 2828539..2830071 1532


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17701.48 Da        Isoelectric Point: 9.8720

>T288633 WP_076947544.1 NZ_LR595855:2827949-2828434 [Raoultella terrigena]
VGHVTAPEPLSAFHQVAEFVSGETVLDDWLKHKGLKNQALGAARTFVVCKKDTKQIAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10164.64 Da        Isoelectric Point: 4.3837

>AT288633 WP_032611697.1 NZ_LR595855:2827695-2827961 [Raoultella terrigena]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPIIEKLL
ARKPQWDM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A085GLQ4

References