Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1068651..1069149 Replicon chromosome
Accession NZ_LR595848
Organism Streptococcus pneumoniae strain 4559 isolate 4559

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FJH52_RS05410 Protein ID WP_001812387.1
Coordinates 1068895..1069149 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag FJH52_RS05405 Protein ID WP_000208080.1
Coordinates 1068651..1068893 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJH52_RS05385 1064473..1065648 + 1176 WP_000886147.1 A/G-specific adenine glycosylase -
FJH52_RS05390 1065703..1066407 + 705 WP_000722076.1 response regulator transcription factor -
FJH52_RS05395 1066400..1067749 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
FJH52_RS05400 1067751..1068560 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
FJH52_RS05405 1068651..1068893 + 243 WP_000208080.1 hypothetical protein Antitoxin
FJH52_RS05410 1068895..1069149 + 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FJH52_RS05415 1069196..1069848 + 653 Protein_1069 potassium channel family protein -
FJH52_RS05420 1070108..1071094 - 987 WP_000204727.1 L-lactate dehydrogenase -
FJH52_RS05425 1071288..1073756 + 2469 WP_001152992.1 DNA gyrase subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.85 Da        Isoelectric Point: 10.7632

>T288624 WP_001812387.1 NZ_LR595848:1068895-1069149 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT288624 WP_000208080.1 NZ_LR595848:1068651-1068893 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References