Detailed information of TA system TA288623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1017370..1018607
• Replicon: chromosome
• Accession: NZ_LR595848
• Organism: Streptococcus pneumoniae strain 4559 isolate 4559

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A098ZIW8
• Locus tag: FJH52_RS05155
• Protein ID: WP_000405362.1
• Coordinates: 1017846..1018607 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: FJH52_RS05150
• Protein ID: WP_000579613.1
• Coordinates: 1017370..1017846 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJH52_RS05130	1012443..1013297	+	855	WP_000900020.1	ADP-ribosylglycohydrolase family protein	-
FJH52_RS05135	1013409..1014293	+	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
FJH52_RS05140	1014456..1016195	+	1740	Protein_1015	alpha-glycosidase	-
FJH52_RS05145	1016470..1016925	+	456	WP_000500474.1	hypothetical protein	-
FJH52_RS05150	1017370..1017846	+	477	WP_000579613.1	helix-turn-helix domain-containing protein	Antitoxin
FJH52_RS05155	1017846..1018607	+	762	WP_000405362.1	toxin PezT	Toxin
FJH52_RS05160	1018635..1019411	+	777	Protein_1019	hypothetical protein	-
FJH52_RS05165	1019339..1019791	+	453	WP_001808559.1	hypothetical protein	-
FJH52_RS05170	1020610..1020969	+	360	WP_000003745.1	hypothetical protein	-
FJH52_RS05175	1020979..1021344	+	366	WP_000263048.1	MobC family plasmid mobilization relaxosome protein	-
FJH52_RS05180	1021331..1023181	+	1851	WP_000261804.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29129.16 Da
• Isoelectric Point: 7.1308

>T288623 WP_000405362.1 NZ_LR595848:1017846-1018607 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18249.67 Da
• Isoelectric Point: 4.3462

>AT288623 WP_000579613.1 NZ_LR595848:1017370-1017846 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

Structures

Toxin

• AlphaFold DB: A0A098ZIW8