Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 453255..453873 Replicon chromosome
Accession NZ_LR595691
Organism Escherichia coli isolate EcMAD1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ECMAD3_RS02095 Protein ID WP_001291435.1
Coordinates 453255..453473 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ECMAD3_RS02100 Protein ID WP_000344800.1
Coordinates 453499..453873 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECMAD3_RS02060 448544..449116 + 573 WP_000779831.1 YbaY family lipoprotein -
ECMAD3_RS02065 449147..449458 - 312 WP_000409911.1 MGMT family protein -
ECMAD3_RS02075 449837..450190 + 354 WP_000878140.1 DUF1428 domain-containing protein -
ECMAD3_RS02080 450232..451782 - 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ECMAD3_RS02085 451946..452416 - 471 WP_000136192.1 YlaC family protein -
ECMAD3_RS02090 452532..453083 - 552 WP_000102568.1 maltose O-acetyltransferase -
ECMAD3_RS02095 453255..453473 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
ECMAD3_RS02100 453499..453873 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ECMAD3_RS02105 454419..457568 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
ECMAD3_RS02110 457591..458784 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T288598 WP_001291435.1 NZ_LR595691:c453473-453255 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT288598 WP_000344800.1 NZ_LR595691:c453873-453499 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References