Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 277668..278239 Replicon plasmid 2
Accession NZ_LR594690
Organism Variovorax sp. WDL1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E5P1_RS33740 Protein ID WP_068674408.1
Coordinates 277898..278239 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2J7VJZ3
Locus tag E5P1_RS33735 Protein ID WP_068674410.1
Coordinates 277668..277901 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5P1_RS33705 272809..273036 + 228 WP_146039514.1 hypothetical protein -
E5P1_RS33710 273306..273698 + 393 WP_083944158.1 DUF2924 domain-containing protein -
E5P1_RS33715 274250..275356 - 1107 WP_083944157.1 acyltransferase -
E5P1_RS33720 275338..275982 - 645 WP_068674416.1 hypothetical protein -
E5P1_RS33725 276009..276428 - 420 WP_068674414.1 hypothetical protein -
E5P1_RS33730 276537..277514 + 978 WP_068674412.1 WYL domain-containing protein -
E5P1_RS33735 277668..277901 + 234 WP_068674410.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E5P1_RS33740 277898..278239 + 342 WP_068674408.1 endoribonuclease MazF Toxin
E5P1_RS33745 278469..280142 - 1674 WP_068674406.1 hypothetical protein -
E5P1_RS33750 280475..281380 - 906 WP_146039517.1 hypothetical protein -
E5P1_RS33755 282012..282233 - 222 WP_146039518.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..816468 816468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-111)

Antitoxin

SpoVT-AbrB domain

(6-46)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12034.87 Da        Isoelectric Point: 9.2734

>T288592 WP_068674408.1 NZ_LR594690:277898-278239 [Variovorax sp. WDL1]
VTGAYVPGRGDVVWLDFDPQAGHEQAGRRPALVLSPATYNGKSGLMLCCPVTNQAKGYPFEVPVTPSSGKVTGVALTDQV
RCLDWRSRNASKFASVTTKCTLDVSAKVKLLLP

Download         Length: 342 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8147.29 Da        Isoelectric Point: 4.3344

>AT288592 WP_068674410.1 NZ_LR594690:277668-277901 [Variovorax sp. WDL1]
MRVEVQKWGNSAAVRVPAPALKDAGMQVGQSLELRVEGGKLVIEPATESLEDLLAQMTPENQHGLALEGPAVGAEAW

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J7VJZ3

References