Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4266060..4266675 Replicon chromosome
Accession NZ_LR594689
Organism Variovorax sp. WDL1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E5P1_RS20765 Protein ID WP_083944520.1
Coordinates 4266388..4266675 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2J7W7W1
Locus tag E5P1_RS20760 Protein ID WP_068680403.1
Coordinates 4266060..4266377 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5P1_RS20735 4262080..4263057 - 978 WP_068680409.1 hypothetical protein -
E5P1_RS20740 4263086..4264252 - 1167 WP_068680408.1 mandelate racemase/muconate lactonizing enzyme family protein -
E5P1_RS20745 4264356..4265252 + 897 WP_068680406.1 LysR family transcriptional regulator -
E5P1_RS20750 4265329..4265655 + 327 WP_102905166.1 hypothetical protein -
E5P1_RS20755 4265631..4265939 - 309 WP_068680404.1 DUF1330 domain-containing protein -
E5P1_RS20760 4266060..4266377 - 318 WP_068680403.1 putative addiction module antidote protein Antitoxin
E5P1_RS20765 4266388..4266675 - 288 WP_083944520.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5P1_RS20770 4266825..4267865 + 1041 WP_068680401.1 dihydroorotase -
E5P1_RS20775 4267862..4268578 + 717 WP_102905168.1 NYN domain-containing protein -
E5P1_RS20780 4268655..4269350 + 696 WP_083944530.1 DUF3025 domain-containing protein -
E5P1_RS20785 4269322..4270359 - 1038 WP_068680398.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
E5P1_RS20790 4270356..4271315 - 960 WP_068680668.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-100)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10789.20 Da        Isoelectric Point: 9.4528

>T288589 WP_083944520.1 NZ_LR594689:c4266675-4266388 [Variovorax sp. WDL1]
MRIHVTDIYHQWINTLTDRAGRARIQVRVDRLAHGNPGQHRYLSGGVSELKIDFGPGYRVYYTERDSELIILLAGGDKST
QQRDIEAAIALARNL

Download         Length: 288 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11240.81 Da        Isoelectric Point: 8.5158

>AT288589 WP_068680403.1 NZ_LR594689:c4266377-4266060 [Variovorax sp. WDL1]
MARTPVRSAPKLRTTPYDVAEQLRTPEEMAAYLDAWLAEAPDDAAGIARALGDIARAKGMSQVARDTGLSRESLYKALSE
NGNPSFATVLKVARALGMRLHAEAA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J7W7W1

References