Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1828196..1829779 Replicon chromosome
Accession NZ_LR594689
Organism Variovorax sp. WDL1

Toxin (Protein)


Gene name hipA Uniprot ID A0A2J7VQ98
Locus tag E5P1_RS09005 Protein ID WP_068685636.1
Coordinates 1828196..1829533 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2J7VQA0
Locus tag E5P1_RS09010 Protein ID WP_068685640.1
Coordinates 1829537..1829779 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5P1_RS08985 1824481..1825506 - 1026 WP_068685629.1 DUF2272 domain-containing protein -
E5P1_RS08990 1825668..1826978 - 1311 WP_068685632.1 amino acid deaminase -
E5P1_RS08995 1827189..1827356 + 168 WP_180988646.1 hypothetical protein -
E5P1_RS09000 1827347..1828192 + 846 WP_068685634.1 M23 family metallopeptidase -
E5P1_RS09005 1828196..1829533 - 1338 WP_068685636.1 type II toxin-antitoxin system HipA family toxin Toxin
E5P1_RS09010 1829537..1829779 - 243 WP_068685640.1 helix-turn-helix domain-containing protein Antitoxin
E5P1_RS09015 1829908..1830660 - 753 WP_083944881.1 lipoprotein-releasing ABC transporter ATP-binding protein LolD -
E5P1_RS09020 1830653..1831909 - 1257 WP_068685642.1 lipoprotein-releasing ABC transporter permease subunit -
E5P1_RS09025 1831990..1834278 - 2289 WP_162487116.1 RHS repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48427.62 Da        Isoelectric Point: 7.7929

>T288588 WP_068685636.1 NZ_LR594689:c1829533-1828196 [Variovorax sp. WDL1]
VGRRSHSQALSIWANGERVGAWRIPARGEPELVYDPSWMASPAGRPLSLSLPLAAHGLKGQVVNSYFDNLLPDSRSIRER
LATRFGTASTDAFALLQAVGRDCVGAIQLLAEDEAPTDLRQISGTPMSPAEVEALLLQTVTPGRLGGLPGEEDVLRISLA
GAQEKTALLWHDQQWMRPHGATPTTHILKLPLGLVGHRQADFSTSVENEWLCLNILQAYGLPVPRCAILGFGAQKVLAVE
RCDRQLHSSGSWLMRLPQEDFCQALGVPSHLKYEADGGPGLLDLATILRQSVRAREDLRTLLAAQLIFWMLAAPDGHAKN
FSIHLLPEGRLRLTPLYDVMSIWPVEGAGPNQFSRHDATLAMAMTGKNKHYRRSTIRRRHFNVTARLCGHGADAEDIVGF
LLDSTPGVLARMEAQLPAGFPAKVAQPILRGLAASAAALEAMPRD

Download         Length: 1338 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8789.17 Da        Isoelectric Point: 7.2034

>AT288588 WP_068685640.1 NZ_LR594689:c1829779-1829537 [Variovorax sp. WDL1]
MRQVLSSPSQLGPLLKSGRRAAGLPQTELAQRMGISQSRISHMELHPESVNLEQLLALFGLLGMELIVQSRSDAPPAQEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7VQ98

Antitoxin

Source ID Structure
AlphaFold DB A0A2J7VQA0

References