Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 609555..610276 Replicon chromosome
Accession NZ_LR594689
Organism Variovorax sp. WDL1

Toxin (Protein)


Gene name vapC Uniprot ID A0A2J7VZ91
Locus tag E5P1_RS02985 Protein ID WP_068679468.1
Coordinates 609824..610276 (+) Length 151 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2J7VZ83
Locus tag E5P1_RS02980 Protein ID WP_068679470.1
Coordinates 609555..609827 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5P1_RS02965 604732..605217 - 486 WP_068679474.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
E5P1_RS02970 605237..605941 - 705 WP_068679598.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
E5P1_RS02975 606046..609540 + 3495 WP_068679472.1 transcription-repair coupling factor -
E5P1_RS02980 609555..609827 + 273 WP_068679470.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E5P1_RS02985 609824..610276 + 453 WP_068679468.1 PIN domain-containing protein Toxin
E5P1_RS02990 610269..610967 + 699 WP_068679595.1 phosphoserine phosphatase SerB -
E5P1_RS02995 611102..612073 + 972 WP_068679466.1 tripartite tricarboxylate transporter substrate binding protein -
E5P1_RS03000 612077..612544 + 468 WP_068679464.1 tripartite tricarboxylate transporter TctB family protein -
E5P1_RS03005 612555..614057 + 1503 WP_068679463.1 tripartite tricarboxylate transporter permease -
E5P1_RS03010 614063..615127 + 1065 WP_068679462.1 Ldh family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-135)

Antitoxin

SpoVT-AbrB domain

(14-49)


Sequences

Toxin        


Download         Length: 151 a.a.        Molecular weight: 16420.70 Da        Isoelectric Point: 6.3323

>T288586 WP_068679468.1 NZ_LR594689:609824-610276 [Variovorax sp. WDL1]
MSAEAATNSLRLLDTNTVFELMRHPGGKVAARLRRLAQEQPDGRVCTSAVVDCELRFGVNRKGSARLADAYTRAMSVIEV
RDLPAAVAPIYADIRTQLEQVGKPIGPNDLLIAAHALALDATLVTHNESEFRRVPGLVVENWLESAHEHE

Download         Length: 453 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9919.37 Da        Isoelectric Point: 4.3525

>AT288586 WP_068679470.1 NZ_LR594689:609555-609827 [Variovorax sp. WDL1]
MSDPHLPARSVRLFRNGANQAVRIPREFELPGNEALMRRDGDTLVIEPVYPVPRKGTLAGLAAVLATMEPLDEEFPDVDK
GLLPLDDVDL

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7VZ91

Antitoxin

Source ID Structure
AlphaFold DB A0A2J7VZ83

References