Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3182498..3184223 Replicon chromosome
Accession NZ_LR594675
Organism Variovorax sp. PBS-H4

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag E5CHR_RS15125 Protein ID WP_162580608.1
Coordinates 3182498..3183370 (+) Length 291 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag E5CHR_RS15130 Protein ID WP_162580609.1
Coordinates 3183396..3184223 (+) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5CHR_RS15095 3178430..3179107 + 678 WP_162580603.1 hypothetical protein -
E5CHR_RS15100 3179104..3179751 + 648 WP_162580604.1 RES family NAD+ phosphorylase -
E5CHR_RS15105 3179755..3179916 - 162 WP_162580605.1 hypothetical protein -
E5CHR_RS15110 3180107..3181081 + 975 WP_162583730.1 tripartite tricarboxylate transporter substrate binding protein -
E5CHR_RS15115 3181089..3181904 + 816 WP_162580606.1 SDR family oxidoreductase -
E5CHR_RS15120 3181924..3182478 + 555 WP_162580607.1 cupin domain-containing protein -
E5CHR_RS15125 3182498..3183370 + 873 WP_162580608.1 alpha/beta hydrolase Toxin
E5CHR_RS15130 3183396..3184223 + 828 WP_162580609.1 IclR family transcriptional regulator Antitoxin
E5CHR_RS15135 3184234..3185070 + 837 WP_162580610.1 SDR family oxidoreductase -
E5CHR_RS15140 3185063..3186760 + 1698 WP_162580611.1 thiamine pyrophosphate-binding protein -
E5CHR_RS15145 3186770..3187570 + 801 WP_162580612.1 aspartate dehydrogenase -
E5CHR_RS15150 3187581..3189059 + 1479 WP_162583731.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(48-282)

Antitoxin

Transcription regulator IclR, C-terminal

(137-256)


Sequences

Toxin        


Download         Length: 291 a.a.        Molecular weight: 30071.52 Da        Isoelectric Point: 6.8129

>T288583 WP_162580608.1 NZ_LR594675:3182498-3183370 [Variovorax sp. PBS-H4]
MSDSTVTDVQRLPVNELARLEARFPARSVPVQGGAFVSVRECGVGPAIVCLHGIGSGSASWLDTALLLESEARLIAWDAP
GYGESTPLAAQAPTAHAYAQRLHGLLDALDVRSCVLVGHSLGALMAASAAREGSPLAPRISNLLLISPAAGYGAASRAQA
QARVRAERLGTLDALGIAGMAAERSGRLVSDHASETARQWVRWNMARLHATGYRQAVDLLCGADLMADLPPAVPVRVACG
ALDVVTTPDACAEVAKRCGVPLELLPEAGHACYVERPAAVAALLRQALAA

Download         Length: 873 bp

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30444.84 Da        Isoelectric Point: 5.7833

>AT288583 WP_162580609.1 NZ_LR594675:3183396-3184223 [Variovorax sp. PBS-H4]
MSNDLIEEGAERYNVPALERGLRMLCEFSRESRTLSAPELARRFDLPRSTVFRLLSTLENMGFLERAEGGRDYRLGLAVL
RLGFEYLASLELTQLGTPLLNRLCEELRTPCNLVVRDGRSIVYVAKVAPPTPFASSVSVGTRLPAHATVLGRILLEDLTL
PQLRALYPEDKLETFSPSTPKTVNELFDMVQADRERGYVLGEGFFESNISTIAAPVRDHSGHIAAALGATITSGHIDENR
MDEMVRRVRETADEISGLLNYAPASKAKVVPLRSA

Download         Length: 828 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References