Detailed information of TA system TA288574

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 2281523..2283258
• Replicon: chromosome
• Accession: NZ_LR594666
• Organism: Variovorax sp. SRS16

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: E5P2_RS11045
• Protein ID: WP_162567120.1
• Coordinates: 2281523..2282386 (+)
• Length: 288 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: E5P2_RS11050
• Protein ID: WP_162567121.1
• Coordinates: 2282419..2283258 (+)
• Length: 280 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5P2_RS11020	2277447..2278700	+	1254	WP_162567116.1	D-amino acid dehydrogenase	-
E5P2_RS11025	2278720..2279460	-	741	WP_162570446.1	ABC transporter substrate-binding protein	-
E5P2_RS11030	2279550..2279972	-	423	WP_162567117.1	hypothetical protein	-
E5P2_RS11035	2280133..2280948	+	816	WP_162567118.1	SDR family oxidoreductase	-
E5P2_RS11040	2280972..2281514	+	543	WP_162567119.1	cupin domain-containing protein	-
E5P2_RS11045	2281523..2282386	+	864	WP_162567120.1	alpha/beta hydrolase	Toxin
E5P2_RS11050	2282419..2283258	+	840	WP_162567121.1	IclR family transcriptional regulator	Antitoxin
E5P2_RS11055	2283278..2284117	+	840	WP_162567122.1	SDR family oxidoreductase	-
E5P2_RS11060	2284110..2285810	+	1701	WP_162567123.1	thiamine pyrophosphate-binding protein	-
E5P2_RS11065	2285825..2286631	+	807	WP_162567124.1	aspartate dehydrogenase	-
E5P2_RS11070	2286645..2288123	+	1479	WP_162567125.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (45-279)

Antitoxin

• Transcription regulator IclR, N-terminal (20-69)

Sequences

Toxin

Protein

• Length: 288 a.a.
• Molecular weight: 30048.61 Da
• Isoelectric Point: 6.3761

>T288574 WP_162567120.1 NZ_LR594666:2281523-2282386 [Variovorax sp. SRS16]
MSDAAMISALPPSEVARLDARFPARRVPVRGGVVSVRACGAGPVIVCLHGIGSGAASWLDTALLLEPHAHLIAWDAPGYG
ESTPVVPEVPMAADYAERLHALLDAMDIESCVLVGHSLGALTAAFAARAGSPLAARIERLVLISPAGGYGAPARAQARQR
VRTERLDTLARLGVAGMATQRSGRLVSDNASELARQWVRWNMARLNDHGYRQAVELLCGGDLQADLPPAMPVRVACGALD
VVTTPAACEEVAIRCGVALELLDGAGHASYVEQPETVAAMLRYVLAS

Nucleotide

• Length: 864 bp

Antitoxin

Protein

• Length: 280 a.a.
• Molecular weight: 30712.13 Da
• Isoelectric Point: 6.0484

>AT288574 WP_162567121.1 NZ_LR594666:2282419-2283258 [Variovorax sp. SRS16]
MTTLGNDVMEEGADRYNVPALERGLRVLCEFSRENRTLSAPELARRFDLPRSTVFRLLTTLESMGFLERAEGGRDYRLGL
AVLRLGFEYLASLELTQLGTPLLQRLCEELRTPCNLVVRDGRSIVYVAKVAPPTPFASSVTVGTRLPAHATVLGRILLED
LSLPQLRALYPEDKLETFSPSTPKTVNELFDMVQSDRDRGYVLGEGFFESNISSIAAPVRDHSGHIVAALGATITSGHIE
EARMDEMVQRVRETADAISGLLNYSPAAKVVALRGGHRA

Nucleotide

• Length: 840 bp