Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 307045..307576 Replicon plasmid 3
Accession NZ_LR594664
Organism Variovorax sp. RA8

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag E5P3_RS34690 Protein ID WP_011114071.1
Coordinates 307045..307326 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag E5P3_RS34695 Protein ID WP_011114070.1
Coordinates 307313..307576 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5P3_RS34680 303034..303294 - 261 WP_162590679.1 GreA/GreB family elongation factor -
E5P3_RS34685 303413..306328 - 2916 WP_003158660.1 Tn3-like element IS1071 family transposase -
E5P3_RS34690 307045..307326 - 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
E5P3_RS34695 307313..307576 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E5P3_RS34700 307749..308177 + 429 WP_011114069.1 antirestriction protein -
E5P3_RS34705 308389..311304 - 2916 WP_003158660.1 Tn3-like element IS1071 family transposase -
E5P3_RS34710 311527..312174 - 648 WP_197894040.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..425299 425299
- inside IScluster/Tn - - 303413..311304 7891


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T288572 WP_011114071.1 NZ_LR594664:c307326-307045 [Variovorax sp. RA8]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT288572 WP_011114070.1 NZ_LR594664:c307576-307313 [Variovorax sp. RA8]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References