Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 250566..251146 Replicon plasmid 2
Accession NZ_LR594663
Organism Variovorax sp. RA8

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E5P3_RS32175 Protein ID WP_162590122.1
Coordinates 250566..250904 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E5P3_RS32180 Protein ID WP_162590123.1
Coordinates 250904..251146 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5P3_RS32145 245641..245937 - 297 WP_162590278.1 type II toxin-antitoxin system RelE/ParE family toxin -
E5P3_RS32150 245934..246242 - 309 WP_162590279.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
E5P3_RS32155 246400..246807 - 408 WP_162590120.1 hypothetical protein -
E5P3_RS32160 247161..247697 - 537 Protein_245 hypothetical protein -
E5P3_RS32165 247737..248015 - 279 Protein_246 transposase domain-containing protein -
E5P3_RS32170 248470..249885 - 1416 WP_162590121.1 transposase -
E5P3_RS32175 250566..250904 - 339 WP_162590122.1 endoribonuclease MazF Toxin
E5P3_RS32180 250904..251146 - 243 WP_162590123.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E5P3_RS32185 251627..252610 + 984 WP_162590124.1 TIM barrel protein -
E5P3_RS32190 252607..253581 + 975 WP_162590125.1 tripartite tricarboxylate transporter substrate binding protein -
E5P3_RS32195 253803..254765 + 963 WP_162590126.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..428971 428971
- flank IS/Tn - - 248470..249885 1415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-106)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 11990.90 Da        Isoelectric Point: 10.2289

>T288571 WP_162590122.1 NZ_LR594663:c250904-250566 [Variovorax sp. RA8]
MVRRYVPEAGDIVWLHFDPQAGHEQAGHRPALVLSPSAYNGKTGLMLCCPLTTQVKGYPFEVKIAAARAGAALADQVKSL
DWVARRASRKGRASAAELAEVRAKAIALIGQP

Download         Length: 339 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8921.27 Da        Isoelectric Point: 5.6244

>AT288571 WP_162590123.1 NZ_LR594663:c251146-250904 [Variovorax sp. RA8]
MHVMVKKWGNSASVRIPAAVMEAARLHLDETVDVREEEGRIVIEPVRPGEFELTRLLARITPENLHGEVSFGPALGKESF

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References