Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 245641..246242 Replicon plasmid 2
Accession NZ_LR594663
Organism Variovorax sp. RA8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E5P3_RS32145 Protein ID WP_162590278.1
Coordinates 245641..245937 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E5P3_RS32150 Protein ID WP_162590279.1
Coordinates 245934..246242 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5P3_RS32125 241792..242649 + 858 WP_162590117.1 hypothetical protein -
E5P3_RS32130 243236..243586 - 351 WP_162590118.1 hypothetical protein -
E5P3_RS32135 243846..244109 + 264 WP_162590119.1 IS66 family insertion sequence element accessory protein TnpB -
E5P3_RS32140 244189..245583 + 1395 Protein_241 IS66 family transposase -
E5P3_RS32145 245641..245937 - 297 WP_162590278.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5P3_RS32150 245934..246242 - 309 WP_162590279.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E5P3_RS32155 246400..246807 - 408 WP_162590120.1 hypothetical protein -
E5P3_RS32160 247161..247697 - 537 Protein_245 hypothetical protein -
E5P3_RS32165 247737..248015 - 279 Protein_246 transposase domain-containing protein -
E5P3_RS32170 248470..249885 - 1416 WP_162590121.1 transposase -
E5P3_RS32175 250566..250904 - 339 WP_162590122.1 endoribonuclease MazF -
E5P3_RS32180 250904..251146 - 243 WP_162590123.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..428971 428971
- flank IS/Tn - - 248470..249885 1415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-53)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11299.03 Da        Isoelectric Point: 5.8792

>T288570 WP_162590278.1 NZ_LR594663:c245937-245641 [Variovorax sp. RA8]
VRLEWSPLAMDDRERIFDFIERDDPRAAIAVDERIATQVLVLLQFPEGGRPGRVEGTRELVVRRTSYIVAYRVGKDCVRI
LRILHSAQLWPGELTDLP

Download         Length: 297 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10895.55 Da        Isoelectric Point: 10.0106

>AT288570 WP_162590279.1 NZ_LR594663:c246242-245934 [Variovorax sp. RA8]
MAANALVQTRIDAEVKERATAVLDNIGLTVSDVMRIVLTRVAKEGALPAGFTVDAAAHDAWFRAKVQEALDDPRPAIPHE
KVNAHFAKRRAAALLKAGEGKA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References