Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 138503..139080 Replicon plasmid 2
Accession NZ_LR594663
Organism Variovorax sp. RA8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E5P3_RS31660 Protein ID WP_162590069.1
Coordinates 138706..139080 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E5P3_RS31655 Protein ID WP_162590273.1
Coordinates 138503..138709 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5P3_RS31640 133590..134576 + 987 WP_162590272.1 D-2-hydroxyacid dehydrogenase family protein -
E5P3_RS31645 135643..136648 - 1006 Protein_142 CoA transferase -
E5P3_RS31650 137033..138148 - 1116 WP_162590068.1 DNA-binding protein -
E5P3_RS31655 138503..138709 + 207 WP_162590273.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E5P3_RS31660 138706..139080 + 375 WP_162590069.1 VapC toxin family PIN domain ribonuclease Toxin
E5P3_RS31665 139089..139922 + 834 WP_162590070.1 integrase -
E5P3_RS31670 139919..141016 - 1098 WP_024815569.1 DNA-binding protein -
E5P3_RS31675 141295..141598 + 304 Protein_148 type II toxin-antitoxin system RelE/ParE family toxin -
E5P3_RS31680 141664..141993 + 330 WP_024815568.1 helix-turn-helix domain-containing protein -
E5P3_RS31685 142094..142318 - 225 Protein_150 hypothetical protein -
E5P3_RS31690 143087..143553 + 467 Protein_151 heme-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..428971 428971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13530.72 Da        Isoelectric Point: 6.2063

>T288569 WP_162590069.1 NZ_LR594663:138706-139080 [Variovorax sp. RA8]
MSVLVDTSVWIDHFRSGNAALAHLVGLDLALTHPMVVVELACGTPPTPREHTLGGLSLLRTCNQATLNEVQELVERERLY
GLGCGLVDMALLASTLITPGARLWTLDRRLLELAQRFDVAHGIH

Download         Length: 375 bp

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7587.72 Da        Isoelectric Point: 5.0807

>AT288569 WP_162590273.1 NZ_LR594663:138503-138709 [Variovorax sp. RA8]
MRTTVTIEDSLFEKALEMADPEMDKAEIFREAIRTFVRVQAGKRLIALGGAAPDIQDVPRRRGEPVSS

Download         Length: 207 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References