Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 111511..112156 Replicon plasmid 2
Accession NZ_LR594663
Organism Variovorax sp. RA8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E5P3_RS31530 Protein ID WP_162590046.1
Coordinates 111511..111936 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E5P3_RS31535 Protein ID WP_162590047.1
Coordinates 111926..112156 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5P3_RS31515 106558..107004 - 447 WP_162590271.1 Lrp/AsnC family transcriptional regulator -
E5P3_RS31520 107170..110670 + 3501 WP_162590044.1 indolepyruvate ferredoxin oxidoreductase family protein -
E5P3_RS31525 110689..111012 + 324 WP_162590045.1 hypothetical protein -
E5P3_RS31530 111511..111936 - 426 WP_162590046.1 PIN domain-containing protein Toxin
E5P3_RS31535 111926..112156 - 231 WP_162590047.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E5P3_RS31540 112847..113071 - 225 WP_162590048.1 exodeoxyribonuclease VII -
E5P3_RS31545 113254..114846 - 1593 WP_162590049.1 exodeoxyribonuclease VII large subunit -
E5P3_RS31550 115062..115604 - 543 WP_162590050.1 helix-turn-helix transcriptional regulator -
E5P3_RS31555 115833..116231 - 399 WP_162590051.1 VOC family protein -
E5P3_RS31560 116585..116857 + 273 WP_162590052.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..428971 428971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

SpoVT-AbrB domain

(5-45)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15767.27 Da        Isoelectric Point: 5.2253

>T288568 WP_162590046.1 NZ_LR594663:c111936-111511 [Variovorax sp. RA8]
MKDRAFADTNVVLYMMSKDAAKAERARAVVAGRPIISVQVLNEIANVARRKLTLPWKEIDEFLQLVRGLCPVEPLTVESH
DLGRALSEKYQLSVYDSMILSSALLSGCDTLYSEDMQDSLRIEKTLTIVNPFSLYGPNFAL

Download         Length: 426 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8570.86 Da        Isoelectric Point: 8.7353

>AT288568 WP_162590047.1 NZ_LR594663:c112156-111926 [Variovorax sp. RA8]
MQVAKWGNSLAIRLPLALVKKLNLSEGDEVRLSVHSPRDLGLTKKPGKEEIVAALREFEGRLPEAFKFDRDDANER

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References