Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2954070..2955793 Replicon chromosome
Accession NZ_LR594659
Organism Variovorax sp. PBL-H6

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag G3W89_RS13900 Protein ID WP_162574627.1
Coordinates 2954070..2954939 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag G3W89_RS13905 Protein ID WP_162574628.1
Coordinates 2954966..2955793 (+) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3W89_RS13875 2949960..2950637 + 678 WP_162574623.1 hypothetical protein -
G3W89_RS13880 2950634..2951281 + 648 WP_162574624.1 RES family NAD+ phosphorylase -
G3W89_RS13885 2951520..2952494 + 975 WP_162577476.1 tripartite tricarboxylate transporter substrate binding protein -
G3W89_RS13890 2952638..2953459 + 822 WP_162574625.1 SDR family oxidoreductase -
G3W89_RS13895 2953495..2954049 + 555 WP_162574626.1 cupin domain-containing protein -
G3W89_RS13900 2954070..2954939 + 870 WP_162574627.1 alpha/beta hydrolase Toxin
G3W89_RS13905 2954966..2955793 + 828 WP_162574628.1 IclR family transcriptional regulator Antitoxin
G3W89_RS13910 2955804..2956643 + 840 WP_162574629.1 SDR family oxidoreductase -
G3W89_RS13915 2956636..2958333 + 1698 WP_162574630.1 thiamine pyrophosphate-binding protein -
G3W89_RS13920 2958343..2959143 + 801 WP_162574631.1 aspartate dehydrogenase -
G3W89_RS13925 2959151..2960629 + 1479 WP_162574632.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(47-281)

Antitoxin

Transcription regulator IclR, N-terminal

(17-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 29992.53 Da        Isoelectric Point: 7.0472

>T288566 WP_162574627.1 NZ_LR594659:2954070-2954939 [Variovorax sp. PBL-H6]
MSDAALIDAQPLPASELARLQARFPARSVSVCGAELSVRECGTGPAIVCLHGIGSGSASWLDTALLLEGEARLVAWDAPG
YGESTPLPAQVPTAQHYAQRLHGLLDALEISSCVLVGHSLGALTAASAARPGSPLASRISRLLLISPAAGYGAASRAQAR
SRVRAERLGTLDALGIAGMATKRSGRLVSDHASETARQWVRWNMARLHETGYRQAIELLCGADLMADLPPAMPVRVACGA
LDVVTTPEACAEVAKQCGVPLELLPVAGHACYVERPAAVAAMLREAVTA

Download         Length: 870 bp

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30362.76 Da        Isoelectric Point: 6.1451

>AT288566 WP_162574628.1 NZ_LR594659:2954966-2955793 [Variovorax sp. PBL-H6]
MSNDLMEEGADRYNVPALERGLRMLCEFSRESRTLSAPELARRFDLPRSTVFRLLSTLENMGFLERAEGGRDYRLGLAVL
RLGFEYLASLELTQLGTPLLNRLCEALRTPCNLVVRDGRSIVYVAKVAPPTPFASSVSVGTRLPAHATVLGRILLEDLTL
PQLRALYPEDKLETFSPSTPKTVNELFDMVQGDRERGYVLGEGFFESNISSIAAPVRDHSGHIAAALGATITSGHIDENR
MDEMVRRVRETADEISGLLNYAPASKAKVVPLRSA

Download         Length: 828 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References