Detailed information of TA system TA288565

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParST/RES-TIGR02293
• Location: 1501706..1502601
• Replicon: chromosome
• Accession: NZ_LR594659
• Organism: Variovorax sp. PBL-H6

Toxin (Protein)

• Gene name: ParT
• Uniprot ID: -
• Locus tag: G3W89_RS07145
• Protein ID: WP_162573434.1
• Coordinates: 1502113..1502601 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: ParS
• Uniprot ID: -
• Locus tag: G3W89_RS07140
• Protein ID: WP_162577367.1
• Coordinates: 1501706..1502116 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3W89_RS07115	1497059..1497721	-	663	WP_162573430.1	formate hydrogenlyase	-
G3W89_RS07120	1497723..1498670	-	948	WP_162573431.1	NADH-quinone oxidoreductase subunit H	-
G3W89_RS07125	1498678..1500702	-	2025	WP_162573432.1	hydrogenase 4 subunit B	-
G3W89_RS07130	1500968..1501165	+	198	WP_162573433.1	CopG family transcriptional regulator	-
G3W89_RS07135	1501308..1501484	-	177	Protein_1420	LysR family transcriptional regulator	-
G3W89_RS07140	1501706..1502116	+	411	WP_162577367.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
G3W89_RS07145	1502113..1502601	+	489	WP_162573434.1	RES family NAD+ phosphorylase	Toxin
G3W89_RS07150	1502668..1503759	+	1092	WP_162573435.1	iron-sulfur cluster carrier protein ApbC	-
G3W89_RS07155	1503770..1504741	+	972	WP_162573436.1	LysR family transcriptional regulator	-
G3W89_RS07160	1504749..1505222	-	474	WP_162573437.1	DUF2501 domain-containing protein	-
G3W89_RS07165	1505407..1507215	+	1809	WP_162573438.1	NAD(P)H-dependent oxidoreductase subunit E	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (4-142)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (9-70)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17310.78 Da
• Isoelectric Point: 7.1676

>T288565 WP_162573434.1 NZ_LR594659:1502113-1502601 [Variovorax sp. PBL-H6]
VTSVWRIAADTREYTADDMSGKGAEKTGGRWNRAGSPVLYAASSVALACLETVVHLNLSGFPLNRFLVRIDVPDEVWVGR
QALSPGTLPVGWSAIPEGRVSVEAGDTWLSGAASALLLVPSVIVPEESNILVNPRHPDAGKLTATKLRPWLFDQRLGARA
AL

Nucleotide

• Length: 489 bp

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14325.41 Da
• Isoelectric Point: 8.4695

>AT288565 WP_162577367.1 NZ_LR594659:1501706-1502116 [Variovorax sp. PBL-H6]
MFRYAPLERVELVKAGVPAQMAVTVAKAMGVSKDSLYQTLGLPRATIDRKLKDGKALSRDESSRVLGIARLVGQAQAIID
ESGEPAGFNAAQWVGQWLAQPVGALGGRTPGELMDTAEGQAIVSNLLDRAVSGAYS

Nucleotide

• Length: 411 bp