Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1020452..1021722 Replicon chromosome
Accession NZ_LR594052
Organism Streptococcus porcinus strain NCTC10924

Toxin (Protein)


Gene name sezT Uniprot ID A0A4V0H7E2
Locus tag FGL17_RS05050 Protein ID WP_017648279.1
Coordinates 1020452..1021246 (-) Length 265 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag FGL17_RS05055 Protein ID WP_017648280.1
Coordinates 1021246..1021722 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL17_RS05040 1016780..1018852 - 2073 WP_069987943.1 AAA family ATPase -
FGL17_RS05045 1019156..1020386 + 1231 Protein_927 IS110 family transposase -
FGL17_RS05050 1020452..1021246 - 795 WP_017648279.1 zeta toxin family protein Toxin
FGL17_RS05055 1021246..1021722 - 477 WP_017648280.1 helix-turn-helix domain-containing protein Antitoxin
FGL17_RS05060 1021792..1022082 - 291 WP_017648281.1 hypothetical protein -
FGL17_RS05065 1022132..1022521 - 390 WP_017648282.1 hypothetical protein -
FGL17_RS05070 1022518..1022745 - 228 WP_017648283.1 hypothetical protein -
FGL17_RS05075 1022799..1023875 - 1077 WP_017648284.1 toprim domain-containing protein -
FGL17_RS05080 1023915..1024553 - 639 WP_017648285.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 265 a.a.        Molecular weight: 30314.37 Da        Isoelectric Point: 6.7533

>T288563 WP_017648279.1 NZ_LR594052:c1021246-1020452 [Streptococcus porcinus]
MRLEEFSKADFQKALQRTIRALTRGKTIPDRPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQIAQLLASKGYQISLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDCIQIYQRDRTCIYNSETDEGSAAEVLQECLFGKWSKVEEEMM
KAGQERLRELCNRDREEKFEKNKS

Download         Length: 795 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18303.73 Da        Isoelectric Point: 4.4582

>AT288563 WP_017648280.1 NZ_LR594052:c1021722-1021246 [Streptococcus porcinus]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVTTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSHNIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERILDMVYHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0H7E2

Antitoxin

Source ID Structure

References