Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2759183..2759754 Replicon chromosome
Accession NZ_LR594051
Organism Enterococcus faecalis strain NCTC8732

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag FGL29_RS14335 Protein ID WP_002360937.1
Coordinates 2759183..2759524 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag FGL29_RS14340 Protein ID WP_002354773.1
Coordinates 2759524..2759754 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL29_RS14325 2755198..2758812 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
FGL29_RS14335 2759183..2759524 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FGL29_RS14340 2759524..2759754 - 231 WP_002354773.1 hypothetical protein Antitoxin
FGL29_RS14345 2760161..2760376 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
FGL29_RS14350 2760515..2761507 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
FGL29_RS14355 2761771..2762400 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
FGL29_RS14365 2763093..2764709 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T288549 WP_002360937.1 NZ_LR594051:c2759524-2759183 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT288549 WP_002354773.1 NZ_LR594051:c2759754-2759524 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References