Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 418962..419544 Replicon chromosome
Accession NZ_LR594051
Organism Enterococcus faecalis strain NCTC8732

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag FGL29_RS02275 Protein ID WP_002355414.1
Coordinates 419236..419544 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag FGL29_RS02270 Protein ID WP_002326825.1
Coordinates 418962..419234 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL29_RS02235 414243..414971 - 729 WP_002355404.1 GntR family transcriptional regulator -
FGL29_RS02240 415148..416074 + 927 WP_002355406.1 hypothetical protein -
FGL29_RS02245 416091..417374 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
FGL29_RS02255 417566..417688 + 123 Protein_395 topoisomerase -
FGL29_RS02260 417763..418659 + 897 WP_002363034.1 ParA family protein -
FGL29_RS02265 418736..418945 + 210 WP_002363035.1 peptide-binding protein -
FGL29_RS02270 418962..419234 + 273 WP_002326825.1 antitoxin Antitoxin
FGL29_RS02275 419236..419544 + 309 WP_002355414.1 zeta toxin family protein Toxin
FGL29_RS02280 419624..420052 - 429 WP_071623404.1 tyrosine-type recombinase/integrase -
FGL29_RS02285 420097..420597 - 501 WP_002363039.1 HAD family hydrolase -
FGL29_RS02290 420602..421369 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
FGL29_RS02300 421857..422282 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
FGL29_RS02305 422299..422814 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
FGL29_RS02310 422825..423757 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ClpL bsh / esp / psaA 386776..531093 144317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T288544 WP_002355414.1 NZ_LR594051:419236-419544 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT288544 WP_002326825.1 NZ_LR594051:418962-419234 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References